biostudies-literaturede Mello LLOConselho Nacional de Desenvolvimento Cient?fico e Tecnol?gicoFunda??o de Amparo ? Pesquisa do Estado de Minas GeraisFunda??o de Amparo ? Pesquisa do Estado de S?o PauloCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior30773-30784https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290960biostudies-literatureUnknown10(28)Schistosomiasis, a neglected tropical disease (NTD) caused by flatworms of the genus Schistosoma, affects more than 250 million people globally. Praziquantel (PZQ) remains the sole therapeutic option, underscoring the need for novel treatments. This study investigates the antischistosomal activity of Eremanthus erythropappus DC. MacLeish (Asteraceae) extracts, and their isolated compounds are against Schistosoma mansoni. In vitro assays revealed that the rinsed extract (LEE) exhibited a significantly lower EC50 (18.1 μg/mL) compared to that of the ethanolic extract (EEE) (191.5 μg/mL), with no cytotoxicity observed at concentrations up to 500 μg/mL. UHPLC-ESI-MS/MS analysis annotated 16 metabolites, including sesquiterpene lactones (STLs) and pentacycACS omegaEremanthus erythropappus as a Source of Antiparasitic Agents: In Vitro and In Vivo Efficacy against Schistosoma mansoni.PMC1229096000100x0ma614APQ-03773-22APQ-00705-222023/08418-6de Moraes Jde Mello LLOAmaro MCAmarante GWAndrade-de-Siqueira AIda Silva Filho AALeal CMfalseEremanthus erythropappus as a Source of Antiparasitic Agents: In Vitro and In Vivo Efficacy against Schistosoma mansoni.Schistosomiasis, a neglected tropical disease (NTD) caused by flatworms of the genus Schistosoma, affects more than 250 million people globally. Praziquantel (PZQ) remains the sole therapeutic option, underscoring the need for novel treatments. This study investigates the antischistosomal activity of Eremanthus erythropappus DC. MacLeish (Asteraceae) extracts, and their isolated compounds are against Schistosoma mansoni. In vitro assays revealed that the rinsed extract (LEE) exhibited a significantly lower EC50 (18.1 μg/mL) compared to that of the ethanolic extract (EEE) (191.5 μg/mL), with no cytotoxicity observed at concentrations up to 500 μg/mL. UHPLC-ESI-MS/MS analysis annotated 16 metabolites, including sesquiterpene lactones (STLs) and pentacyc2025-01-01T00:00:00Z2025 Jul2026-05-09T19:10:21.657Z2026-04-08T01:10:43.147ZS-EPMC122909604072775210.1021/acsomega.5c03005