biostudies-literatureUnknown40(9)Gupta AKidney genetic services are being created worldwide, revolutionising the way in which we manage families with suspected monogenic kidney disease. There is potential to learn from one another, whether one is just embarking on this journey or within an established kidney genetics service model with aspirations to optimise it further. This concluding portion of our two-part educational review explores the global efforts to integrate genomics into nephrology. We discuss key considerations for establishing kidney genetics services and share insights from successful implementation in Australia, India, the United Kingdom (UK) and the United States (US), through case studies. Widespread integration of genomics within nephrology still faces barriers including limited genomics education among clinicPediatric nephrology (Berlin, Germany)2779-2793https://www.ebi.ac.uk/biostudies/studies/S-EPMC12296791biostudies-literatureNext-generation nephrology: part 2-mainstreaming genomics in nephrology, a global perspective.PMC12296791Quinlan CGupta ASinha RMajmundar AJayasinghe KSampson MGMann NfalseNext-generation nephrology: part 2-mainstreaming genomics in nephrology, a global perspective.Kidney genetic services are being created worldwide, revolutionising the way in which we manage families with suspected monogenic kidney disease. There is potential to learn from one another, whether one is just embarking on this journey or within an established kidney genetics service model with aspirations to optimise it further. This concluding portion of our two-part educational review explores the global efforts to integrate genomics into nephrology. We discuss key considerations for establishing kidney genetics services and share insights from successful implementation in Australia, India, the United Kingdom (UK) and the United States (US), through case studies. Widespread integration of genomics within nephrology still faces barriers including limited genomics education among clinic2025-01-01T00:00:00Z2025 Sep2025-08-28T03:09:14.306Z2025-08-28T03:09:14.306ZS-EPMC122967914001955510.1007/s00467-025-06711-7