{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nyakarahuka L"],"funding":["CDC HHS"],"pagination":["1015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12298680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(7)"],"pubmed_abstract":["In Africa, Rift Valley Fever poses a substantial risk to animal health, and human cases occur after contact with infected animals or their tissues. RVF has re-emerged in Uganda after nearly five decades, with multiple outbreaks recorded since 2016. We investigated a unique RVF outbreak associated with an animal abortion storm of 30 events and human cases on a dairy farm in Mbarara District, Western Uganda, in February 2023. Genomic analysis was performed, comparing animal and human RVF viruses (RVFV) circulating in the region. A cluster of thirteen human RVF cases and nine PCR-positive animals could directly be linked with the abortion storm. Overall, during the year 2023, we confirmed 61 human RVFV cases across Uganda, 88.5% of which were reported to have had direct contact with livestock, and a high case fatality rate of 31%. We recommend implementing extensive health education programs in affected communities and using sustainable mosquito control strategies to limit transmission in livestock, coupled with initiating animal vaccination trials in Uganda."],"journal":["Viruses"],"pubmed_title":["Rift Valley Fever Outbreak Investigation Associated with a Dairy Farm Abortion Storm, Mbarara District, Western Uganda, 2023."],"pmcid":["PMC12298680"],"funding_grant_id":["RFA-CK-13-001."],"pubmed_authors":["Whitesell A","Nyakarahuka L","Lutwama JJ","Baluku J","Torach CR","Wandera N","Shoemaker TR","Muwanguzi D","Namanya D","Klena JD","Nankya A","Montgomery JM","Balinandi SK","Telford C","Kabami Z","Mulei S","Mutesi J","Kyondo J","Muhindo R","Mugabi F","Nambuya M","Whitmer S","Muhereza D","Tumusiime A"],"additional_accession":[]},"is_claimable":false,"name":"Rift Valley Fever Outbreak Investigation Associated with a Dairy Farm Abortion Storm, Mbarara District, Western Uganda, 2023.","description":"In Africa, Rift Valley Fever poses a substantial risk to animal health, and human cases occur after contact with infected animals or their tissues. RVF has re-emerged in Uganda after nearly five decades, with multiple outbreaks recorded since 2016. We investigated a unique RVF outbreak associated with an animal abortion storm of 30 events and human cases on a dairy farm in Mbarara District, Western Uganda, in February 2023. Genomic analysis was performed, comparing animal and human RVF viruses (RVFV) circulating in the region. A cluster of thirteen human RVF cases and nine PCR-positive animals could directly be linked with the abortion storm. Overall, during the year 2023, we confirmed 61 human RVFV cases across Uganda, 88.5% of which were reported to have had direct contact with livestock, and a high case fatality rate of 31%. We recommend implementing extensive health education programs in affected communities and using sustainable mosquito control strategies to limit transmission in livestock, coupled with initiating animal vaccination trials in Uganda.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2025-08-24T03:06:12.568Z","creation":"2025-08-24T03:06:12.568Z"},"accession":"S-EPMC12298680","cross_references":{"pubmed":["40733631"],"doi":["10.3390/v17071015"]}}