{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["Natural Sciences and Engineering Research Council of Canada","Agriculture and Agrifoods Canada, AgSci BioCluster"],"pagination":["1463"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["Mannosyl erythritol lipids (MELs) are glycolipid biosurfactants produced by <i>Ustilaginomycete</i> yeasts. The MEL biosynthetic pathway has been characterized in <i>Ustilago maydis</i> where a putative transporter encoded by <i>MMF1</i> is required for the secretion of the glycolipid surfactant to the extracellular space. The anamorphic yeast <i>Moesziomyces antarcticus</i> is a prolific producer of MELs, but the mechanism of MEL secretion is less well characterized than in <i>U. maydis</i>. Homologous recombination was employed to generate a disruption of the <i>MMF1</i> gene in <i>M. antarcticus</i> JCM10317. This mutation did not prevent the intracellular accumulation of MEL species but did result in significantly reduced secretion of the conventional MEL-A, MEL-B and MEL-C species det"],"journal":["Microorganisms"],"pubmed_title":["&lt;i&gt;Moesziomyces antarcticus MMF1&lt;/i&gt; Has a Role in the Secretion of Mannosylerythritol Lipids."],"pmcid":["PMC12299085"],"funding_grant_id":["RGPIN-2021-02898","53"],"pubmed_authors":["Stuart DT","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Moesziomyces antarcticus MMF1&lt;/i&gt; Has a Role in the Secretion of Mannosylerythritol Lipids.","description":"Mannosyl erythritol lipids (MELs) are glycolipid biosurfactants produced by <i>Ustilaginomycete</i> yeasts. The MEL biosynthetic pathway has been characterized in <i>Ustilago maydis</i> where a putative transporter encoded by <i>MMF1</i> is required for the secretion of the glycolipid surfactant to the extracellular space. The anamorphic yeast <i>Moesziomyces antarcticus</i> is a prolific producer of MELs, but the mechanism of MEL secretion is less well characterized than in <i>U. maydis</i>. Homologous recombination was employed to generate a disruption of the <i>MMF1</i> gene in <i>M. antarcticus</i> JCM10317. This mutation did not prevent the intracellular accumulation of MEL species but did result in significantly reduced secretion of the conventional MEL-A, MEL-B and MEL-C species det","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-30T03:28:53.766Z","creation":"2025-08-14T03:05:53.311Z"},"accession":"S-EPMC12299085","cross_references":{"pubmed":["40731973"],"doi":["10.3390/microorganisms13071463"]}}