biostudies-literatureBezerra ACMUniversidade Estadual do Norte Fluminense931https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299093biostudies-literatureUnknown17(7)<b>Background/Objective</b>: Cancer stem cells (CSCs) are a self-renewing subpopulation within tumors that contribute to heterogeneity and resistance to conventional cancer therapies, including chemotherapy and radiotherapy. Despite growing interest in CSCs as therapeutic targets, effective compounds against these cells remain limited. This systematic review aims to assess the potential of metal-based coordination complexes as anti-CSC agents in preclinical models. <b>Methods</b>: A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twenty-seven original in vitro studies were included, all evaluating the cytotoxic effects of metal-based compounds on cancer cell lines enriched with CSC subpopulatioPharmaceuticsPreclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review.PMC12299093Projeto PAPIC - UENF SEI\260002\007142\2024Bezerra ACMBaptista LECVCouto MNAKanashiro MMfalsePreclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review.<b>Background/Objective</b>: Cancer stem cells (CSCs) are a self-renewing subpopulation within tumors that contribute to heterogeneity and resistance to conventional cancer therapies, including chemotherapy and radiotherapy. Despite growing interest in CSCs as therapeutic targets, effective compounds against these cells remain limited. This systematic review aims to assess the potential of metal-based coordination complexes as anti-CSC agents in preclinical models. <b>Methods</b>: A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twenty-seven original in vitro studies were included, all evaluating the cytotoxic effects of metal-based compounds on cancer cell lines enriched with CSC subpopulatio2025-01-01T00:00:00Z2025 Jul2025-08-18T09:54:12.695Z2025-08-18T09:54:12.695ZS-EPMC122990934073313910.3390/pharmaceutics17070931