{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Heath and Medical Research Fund"],"pagination":["1086"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(7)"],"pubmed_abstract":["<h4>Background</h4>Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota's role in sleep regulation through the gut-brain axis. This systematic review aims to summarise current evidence on the role of gut microbiota alterations in insomnia.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Library through November 2024 for case-control studies comparing gut microbiota in insomnia subjects and controls. The primary outcome was changes in microbiota diversity and bacteria taxonomy.<h4>Results</h4>We included 15 case-control studies from 14 articles, consisting of 1321 subjects (603 insomnia; 718 controls). Eight studies showed reduced alpha diversity and eleven showed altered be"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies."],"pmcid":["PMC12299568"],"funding_grant_id":["24230222"],"pubmed_authors":["Chan YL","Chan FKL","Li C","Su Q","Chan NY","Wang Y","Chen S","Ng SC","Xie S","Wing YK"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies.","description":"<h4>Background</h4>Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota's role in sleep regulation through the gut-brain axis. This systematic review aims to summarise current evidence on the role of gut microbiota alterations in insomnia.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Library through November 2024 for case-control studies comparing gut microbiota in insomnia subjects and controls. The primary outcome was changes in microbiota diversity and bacteria taxonomy.<h4>Results</h4>We included 15 case-control studies from 14 articles, consisting of 1321 subjects (603 insomnia; 718 controls). Eight studies showed reduced alpha diversity and eleven showed altered be","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2025-08-17T03:06:24.18Z","creation":"2025-08-17T03:06:24.18Z"},"accession":"S-EPMC12299568","cross_references":{"pubmed":["40724588"],"doi":["10.3390/life15071086"]}}