{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun Z"],"funding":["Guangdong Basic and Applied Basic Research Foundation"],"pagination":["933"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(7)"],"pubmed_abstract":["<b><i>Aim of the study:</i></b> Traditional Chinese herbs have a unique therapeutic effect on stroke and numerous successful clinical cases. However, these clinical cases are highly dispersed, creating challenges for translational research. This study employs a new paradigm to identify treatment patterns and the active compound interactions contained within these clinical cases, with experimental validation after target screening. <b><i>Methods and Materials:</i></b> Stroke-related targets were identified through GEO, DisGeNET, and Genecards. Active ingredients were extracted from BATMAN-TCM 2.0. All herbs and diseases were confirmed by the Pharmacopoeia of the People's Republic of China (2020 edition) and Medical Subject Heading (MeSH). All networks in this study were constructed by Cytos"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Paeoniflorin Improves Stroke by Modulating the ESR1 Pathway: Data Mining and Validation Based on Network Approaches."],"pmcid":["PMC12299786"],"funding_grant_id":["2023A1515010150"],"pubmed_authors":["Zhou M","Yung KKL","Feng Z","Zhang Z","Hu K","Chu J","Wang X","Wang Z","Qi S","Sun Z","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Paeoniflorin Improves Stroke by Modulating the ESR1 Pathway: Data Mining and Validation Based on Network Approaches.","description":"<b><i>Aim of the study:</i></b> Traditional Chinese herbs have a unique therapeutic effect on stroke and numerous successful clinical cases. However, these clinical cases are highly dispersed, creating challenges for translational research. This study employs a new paradigm to identify treatment patterns and the active compound interactions contained within these clinical cases, with experimental validation after target screening. <b><i>Methods and Materials:</i></b> Stroke-related targets were identified through GEO, DisGeNET, and Genecards. Active ingredients were extracted from BATMAN-TCM 2.0. All herbs and diseases were confirmed by the Pharmacopoeia of the People's Republic of China (2020 edition) and Medical Subject Heading (MeSH). All networks in this study were constructed by Cytos","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-07-04T03:18:18.917Z","creation":"2025-08-14T03:06:32.053Z"},"accession":"S-EPMC12299786","cross_references":{"pubmed":["40732222"],"doi":["10.3390/ph18070933"]}}