{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nittayaboon K"],"funding":["National Science, Research and Innovation Fund (NSRF) and Prince of Songkla University","Postdoctoral Fellowship program from Faculty of Medicine, Prince of Songkla University"],"pagination":["1050"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(7)"],"pubmed_abstract":["<b>Background:</b> Bone marrow mesenchymal stem cells (BM-MSCs) are significant in chemo- and radiotherapy resistance. Previous research has focused on BM-MSCs, demonstrating their functional involvement in cancer progression as mediators in the tumor microenvironment. They play multiple roles in tumorigenesis, angiogenesis, and metastasis. BM-MSC-derived exosomes (BM-MSCs-exo) are small vesicles, typically 50-300 nm in diameter, isolated from BM-MSCs. Some studies have demonstrated the tumor-suppressive effects of BM-MSCs-exo. <b>Objective:</b> This study aimed to investigate their role in modulating the impact of chemoradiotherapy (CRT) in different types of cervical cancer spheroid cells. <b>Methods:</b> The spheroids after treatment were subject to size measurement, cell viability, and"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Modulate Chemoradiotherapy Response in Cervical Cancer Spheroids."],"pmcid":["PMC12299787"],"funding_grant_id":["MED6701155S"],"pubmed_authors":["Nittayaboon K","Bissanum R","Navakanitworakul R","Molika P","Chumsuwan N","Leetanaporn K"],"additional_accession":[]},"is_claimable":false,"name":"Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Modulate Chemoradiotherapy Response in Cervical Cancer Spheroids.","description":"<b>Background:</b> Bone marrow mesenchymal stem cells (BM-MSCs) are significant in chemo- and radiotherapy resistance. Previous research has focused on BM-MSCs, demonstrating their functional involvement in cancer progression as mediators in the tumor microenvironment. They play multiple roles in tumorigenesis, angiogenesis, and metastasis. BM-MSC-derived exosomes (BM-MSCs-exo) are small vesicles, typically 50-300 nm in diameter, isolated from BM-MSCs. Some studies have demonstrated the tumor-suppressive effects of BM-MSCs-exo. <b>Objective:</b> This study aimed to investigate their role in modulating the impact of chemoradiotherapy (CRT) in different types of cervical cancer spheroid cells. <b>Methods:</b> The spheroids after treatment were subject to size measurement, cell viability, and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2025-08-16T03:07:00.037Z","creation":"2025-08-16T03:07:00.037Z"},"accession":"S-EPMC12299787","cross_references":{"pubmed":["40732337"],"doi":["10.3390/ph18071050"]}}