{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferreira CS"],"funding":["Université de Strasbourg the Agence Nationale de la Recherche '","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-CAPES","Fundação de Amparo à Pesquisa de Minas Gerais-FAPEMIG","Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq","LabEx Chemistry of Complex Systems","Foundation Jean-Marie Lehn/Interdisciplinary Thematic Institute SysChem/IdExUnistra"],"pagination":["952"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(7)"],"pubmed_abstract":["<b>Background/Objectives:</b> The increasing prevalence of multidrug-resistant bacteria presents a major global health challenge, prompting a search for innovative antimicrobial strategies. This study aimed to develop and evaluate a novel nanobiostructure combining alumina nanoparticles (NPs) with the antimicrobial peptide lunatin-1 (Lun-1), forming peptide-functionalized nanofilaments. The main objective was to investigate how the site of peptide functionalization (C-terminal vs. N-terminal) affects membrane interactions and antibacterial activity. <b>Methods</b>: NP-peptide conjugates were synthesized via covalent bonding between lun-1 and alumina NP and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential analysis, dynamic light scattering "],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Influence of Peptide Conjugation Sites on Lunatin-Alumina Nanoparticles: Implications for Membrane Interaction and Antimicrobial Activity."],"pmcid":["PMC12299903"],"funding_grant_id":["CAPES- COFECUB program 88881.879071/2023-01","ANR-10-IDEX-0002","10-LABX-0026_CSC","438054/2018-0","APQ-02238-17","RED-00185-23","projects Naturalarsenal 19-AMRB-0004-02, AmphiPep 20-CE18-0021, and SAFEST 21-CE18-0043)"],"pubmed_authors":["Nunes LO","Salnikov ES","Bechinger B","Verly RM","Kato KC","Ferreira CS","Costa LMF","de Souza KR","de Castro Pimenta AM","Araujo GP","Resende JM","Martins HR"],"additional_accession":[]},"is_claimable":false,"name":"Influence of Peptide Conjugation Sites on Lunatin-Alumina Nanoparticles: Implications for Membrane Interaction and Antimicrobial Activity.","description":"<b>Background/Objectives:</b> The increasing prevalence of multidrug-resistant bacteria presents a major global health challenge, prompting a search for innovative antimicrobial strategies. This study aimed to develop and evaluate a novel nanobiostructure combining alumina nanoparticles (NPs) with the antimicrobial peptide lunatin-1 (Lun-1), forming peptide-functionalized nanofilaments. The main objective was to investigate how the site of peptide functionalization (C-terminal vs. N-terminal) affects membrane interactions and antibacterial activity. <b>Methods</b>: NP-peptide conjugates were synthesized via covalent bonding between lun-1 and alumina NP and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential analysis, dynamic light scattering ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-08-13T03:04:44.249Z","creation":"2025-08-13T03:04:44.249Z"},"accession":"S-EPMC12299903","cross_references":{"pubmed":["40732243"],"doi":["10.3390/ph18070952"]}}