{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(7)"],"submitter":["Saucedo-Montalvo MC"],"pubmed_abstract":["<i>Triatoma dimidiata</i> is a widely distributed vector of <i>Trypanosoma cruzi</i> in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestation and emerging resistance have limited its long-term effectiveness. In this study, we analyzed the genetic diversity and population structure of <i>T. dimidiata</i> from Veracruz, Oaxaca, and Yucatan using mitochondrial markers (cyt b and ND4) and screened for knockdown resistance (kdr)-type mutations in the voltage-gated sodium channel (VGSC) gene. High haplotype diversity and regional differentiation were observed, with most genetic variation occurring between populations. The ND4 marker provided greater resolution "],"journal":["Tropical medicine and infectious disease"],"pagination":["182"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12299954"],"repository":["biostudies-literature"],"pubmed_title":["First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct &lt;i&gt;Triatoma dimidiata&lt;/i&gt;, Vector of Chagas Disease in Mexico."],"pmcid":["PMC12299954"],"pubmed_authors":["Gutierrez-Rodriguez SM","Reyes-Solis GDC","Lopez-Monroy B","Davila-Barboza JA","Favela-Lara S","Flores AE","Saucedo-Montalvo MC","Bobadilla-Utrera C","Rodriguez-Sanchez IP"],"additional_accession":[]},"is_claimable":false,"name":"First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct &lt;i&gt;Triatoma dimidiata&lt;/i&gt;, Vector of Chagas Disease in Mexico.","description":"<i>Triatoma dimidiata</i> is a widely distributed vector of <i>Trypanosoma cruzi</i> in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestation and emerging resistance have limited its long-term effectiveness. In this study, we analyzed the genetic diversity and population structure of <i>T. dimidiata</i> from Veracruz, Oaxaca, and Yucatan using mitochondrial markers (cyt b and ND4) and screened for knockdown resistance (kdr)-type mutations in the voltage-gated sodium channel (VGSC) gene. High haplotype diversity and regional differentiation were observed, with most genetic variation occurring between populations. The ND4 marker provided greater resolution ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-08-17T03:05:59.259Z","creation":"2025-08-17T03:05:59.259Z"},"accession":"S-EPMC12299954","cross_references":{"pubmed":["40711059"],"doi":["10.3390/tropicalmed10070182"]}}