{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu J"],"funding":["National Natural Science Foundation of China","Open Fund of Yichang City Clinical Research Center for Mental Disorders"],"pagination":["821-831"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12301682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(7)"],"pubmed_abstract":["Objective
To examine the effect of Soyasaponin Bb on morphine withdrawal-induced anxiety-like behaviors in male mice and the corresponding mechanism.Methods
The chronic intermittent escalating-dose morphine administration paradigm and spontaneous withdrawal were used to induce anxiety-like behaviors in male mice. Open field test (OFT) and elevated plus maze test (EPM) were used to evaluate anxiety-like behaviors. Soyasaponin Bb was intragastrically administered. Western blot was used to monitor the level of GSK-3β, Nrf2, and superoxidase dismutase in the basolateral amygdala (BLA). Virus-mediated gene overexpression and knockdown were used to manipulate the expression of GSK-3β and Nrf2 in the BLA. Two-way analysis of variance followed by Tukey's test were used to make comp"],"journal":["Psychiatry investigation"],"pubmed_title":["Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling."],"pmcid":["PMC12301682"],"funding_grant_id":["81971248","YCXL-23-13","31200814"],"pubmed_authors":["Wu J","Li Z","Liu L","Lu Y","Xiao Z","Shu Y","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling.","description":"Objective
To examine the effect of Soyasaponin Bb on morphine withdrawal-induced anxiety-like behaviors in male mice and the corresponding mechanism.Methods
The chronic intermittent escalating-dose morphine administration paradigm and spontaneous withdrawal were used to induce anxiety-like behaviors in male mice. Open field test (OFT) and elevated plus maze test (EPM) were used to evaluate anxiety-like behaviors. Soyasaponin Bb was intragastrically administered. Western blot was used to monitor the level of GSK-3β, Nrf2, and superoxidase dismutase in the basolateral amygdala (BLA). Virus-mediated gene overexpression and knockdown were used to manipulate the expression of GSK-3β and Nrf2 in the BLA. Two-way analysis of variance followed by Tukey's test were used to make comp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T16:02:49.667Z","creation":"2025-08-27T03:06:25.799Z"},"accession":"S-EPMC12301682","cross_references":{"pubmed":["40708479"],"doi":["10.30773/pi.2025.0091"]}}