{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Le K"],"pubmed_abstract":["<h4>Introduction</h4>Monoosteophils, derived from LL-37-treated monocytes, are a novel type of calcifying/bone forming cells. We have shown that monoosteophils can form bone-like nodules <i>in vitro</i> and accelerate bone repair in a drilled femur defect model. Here, we explored the bone repair function of monoosteophils in a mouse model of critical-sized calvarial defect and the mechanism of bone nodule formation of monoosteophils <i>in vitro</i>.<h4>Methods</h4>Human monocytes were isolated from peripheral blood and differentiated into monoosteophils. Critical-sized (5 mm-diameter) calvarial defects in the parietal bone of adult male NOD/SCID mice were implanted with either 1-day untreated human monocytes, 1-day LL-37 treated human monocytes (monoosteophils), 1-day human monocytes plus "],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["1583496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12301765"],"repository":["biostudies-literature"],"pubmed_title":["A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils."],"pmcid":["PMC12301765"],"pubmed_authors":["Le K","Liu H","Shively JE","Olafsen T","Li Z","Zhang Z","Fong Y","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils.","description":"<h4>Introduction</h4>Monoosteophils, derived from LL-37-treated monocytes, are a novel type of calcifying/bone forming cells. We have shown that monoosteophils can form bone-like nodules <i>in vitro</i> and accelerate bone repair in a drilled femur defect model. Here, we explored the bone repair function of monoosteophils in a mouse model of critical-sized calvarial defect and the mechanism of bone nodule formation of monoosteophils <i>in vitro</i>.<h4>Methods</h4>Human monocytes were isolated from peripheral blood and differentiated into monoosteophils. Critical-sized (5 mm-diameter) calvarial defects in the parietal bone of adult male NOD/SCID mice were implanted with either 1-day untreated human monocytes, 1-day LL-37 treated human monocytes (monoosteophils), 1-day human monocytes plus ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-08-24T03:04:20.619Z","creation":"2025-08-21T09:52:57.25Z"},"accession":"S-EPMC12301765","cross_references":{"pubmed":["40727647"],"doi":["10.3389/fbioe.2025.1583496"]}}