{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zinchuk AV"],"funding":["National Institute of Neurological Disorders and Stroke","American Heart Association","American Academy of Sleep Medicine Foundation","NIA NIH HHS","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","Parker B Francis Foundation","NINDS NIH HHS","National Institute on Aging"],"pagination":["2401183"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12301966"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(2)"],"pubmed_abstract":["<h4>Background</h4>Obstructive sleep apnoea (OSA) is associated with neurocognitive dysfunction. However, randomised trials evaluating the effects of continuous positive airway pressure (CPAP) on neurocognition in those without dementia do not show a benefit. We thus aimed to assess whether arousal threshold (ArTH) modifies the effect of CPAP on neurocognitive function.<h4>Methods</h4>We performed a secondary analysis of a randomised, sham-controlled trial (Apnea Positive Pressure Long-term Efficacy Study (APPLES); ClinicalTrials.gov: NCT00051363). ArTH was estimated from polysomnography using a translatable method. Neurocognitive outcomes included the Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD) score (executive function, primary outcome), with the Pathfinder Number Test total"],"journal":["The European respiratory journal"],"pubmed_title":["Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea."],"pmcid":["PMC12301966"],"funding_grant_id":["L30 HL143623","UG3HL169648","R01 HL153874","R01 HL158765","R01 AG080609","UH3 NS113769","19CDA34660137","UH3NS113769","K23 HL159259","K24 HL132093","228SR20","R01 AG0668870, R01 AG080609","UG3 HL169648","P01 HL149630","R01 HL146697","R21 HL161766","15SDG25890059","R01 HL128658","R01HL146697","K23HL159259","R01 HL102321"],"pubmed_authors":["Azarbarzin A","Yaggi HK","Kushida CA","Walker A","Sands SA","Varga AW","Alex RM","Zinchuk AV","Wellman A"],"additional_accession":[]},"is_claimable":false,"name":"Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea.","description":"<h4>Background</h4>Obstructive sleep apnoea (OSA) is associated with neurocognitive dysfunction. However, randomised trials evaluating the effects of continuous positive airway pressure (CPAP) on neurocognition in those without dementia do not show a benefit. We thus aimed to assess whether arousal threshold (ArTH) modifies the effect of CPAP on neurocognitive function.<h4>Methods</h4>We performed a secondary analysis of a randomised, sham-controlled trial (Apnea Positive Pressure Long-term Efficacy Study (APPLES); ClinicalTrials.gov: NCT00051363). ArTH was estimated from polysomnography using a translatable method. Neurocognitive outcomes included the Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD) score (executive function, primary outcome), with the Pathfinder Number Test total","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-03-17T16:08:56.387Z","creation":"2025-08-18T09:52:54.733Z"},"accession":"S-EPMC12301966","cross_references":{"pubmed":["39572221"],"doi":["10.1183/13993003.01183-2024"]}}