biostudies-literatureUnknown74Farag MAAlexander von Humboldt-Stiftung<h4>Introduction</h4>Climate change poses various threats to marine life, particularly in shallow tropical waters.<h4>Objective</h4>The impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated.<h4>Methods</h4>To illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling. UHPLC-MS coupled with chemometrics and GNPS molecular networking was employed for sample classification and identification of markers unique to stress responses in each organism.<h4>Results</h4>Several compounds with bioactive functions, including peptides and terpenoids, were reported for the first tiJournal of advanced research255-268https://www.ebi.ac.uk/biostudies/studies/S-EPMC12302363biostudies-literatureMetabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics.PMC12302363Afifi SMStuhr MKunzmann AWessjohann LAFarag MASaied DBKuhnhold HWestphal HfalseMetabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics.<h4>Introduction</h4>Climate change poses various threats to marine life, particularly in shallow tropical waters.<h4>Objective</h4>The impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated.<h4>Methods</h4>To illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling. UHPLC-MS coupled with chemometrics and GNPS molecular networking was employed for sample classification and identification of markers unique to stress responses in each organism.<h4>Results</h4>Several compounds with bioactive functions, including peptides and terpenoids, were reported for the first ti2025-01-01T00:00:00Z2025 Aug2026-03-27T17:01:13.49Z2025-08-28T03:09:13.19ZS-EPMC123023633941422910.1016/j.jare.2024.10.007