{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kobelyatskaya AA"],"funding":["IDB RAS Government basic research programme"],"pagination":["49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12302907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Insulators are the multifunctional DNA binding proteins that perform architectural functions and regulate gene transcription. Although insulators have a well-established role in genome organization, it is still unclear how insulator proteins affect the control of tissue-specific processes. The Drosophila insulator BEAF32 (Boundary Element-Associated Factor of 32 kD) is a component of chromatin complexes found in open chromatin regions containing promoters of housekeeping genes. BEAF32 knockout impairs oogenesis and female fertility suggesting its specific functions during oogenesis.Results
To get a better understanding of BEAF32 roles in oogenesis, we first examined its ovarian binding targets and discovered an enrichment of its localization sites in the promoter"],"journal":["Epigenetics & chromatin"],"pubmed_title":["Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries."],"pmcid":["PMC12302907"],"funding_grant_id":["IDB RAS Government basic research programme 0088–2024–0010","IDB RAS Government basic research programme 0088-2024-0010"],"pubmed_authors":["Kwon DA","Kobelyatskaya AA","Shchukina AA","Morgunova V","Sokolova O","Funikov S","Kalmykova A","Kalinkin A"],"additional_accession":[]},"is_claimable":false,"name":"Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries.","description":"Background
Insulators are the multifunctional DNA binding proteins that perform architectural functions and regulate gene transcription. Although insulators have a well-established role in genome organization, it is still unclear how insulator proteins affect the control of tissue-specific processes. The Drosophila insulator BEAF32 (Boundary Element-Associated Factor of 32 kD) is a component of chromatin complexes found in open chromatin regions containing promoters of housekeeping genes. BEAF32 knockout impairs oogenesis and female fertility suggesting its specific functions during oogenesis.Results
To get a better understanding of BEAF32 roles in oogenesis, we first examined its ovarian binding targets and discovered an enrichment of its localization sites in the promoter","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T05:58:50.237Z","creation":"2025-08-27T03:10:15.343Z"},"accession":"S-EPMC12302907","cross_references":{"pubmed":["40717082"],"doi":["10.1186/s13072-025-00613-6"]}}