biostudies-literatureUnknown34(6)Haq AU<p>Objectives: This meta-analysis compared the efficacy and safety of drug-coated balloon (DCB) angioplasty with drug-eluting stent (DES) for the treatment of de novo coronary artery disease.<h4>Methods</h4>Following PRISMA guidelines, we conducted a systematic search of major databases, including Cochrane, Medline, Embase and ClinicalTrials.gov, to identify eligible randomized controlled trials (RCTs) comparing DCB and DES. Mantel-Haenszel model was used for dichotomous outcomes. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model using RevMan software.<h4>Results</h4>Thirteen RCTs with a total of 4,686 patients were included. The analysis found no significant differences between DCB and DES for all-cause mortality (RR: 1.11, 95% CI: 0.81-1.5Medical principles and practice : international journal of the Kuwait University, Health Science Centre544-554https://www.ebi.ac.uk/biostudies/studies/S-EPMC12303576biostudies-literatureEfficacy of Drug-Coated Balloon versus Drug-Eluting Stent for Patients with De Novo Coronary Artery Disease: A Systematic Review and Meta-Analysis.PMC12303576Yousaf HSuhail ANadeem BBungish MKShahid MARehman MEUAhmed RAlsubari AAAMAAhmad ANawal AWazir HUHaq AUMaqbool HHassan HAhmad Cheema HKhan MAAhsan WfalseEfficacy of Drug-Coated Balloon versus Drug-Eluting Stent for Patients with De Novo Coronary Artery Disease: A Systematic Review and Meta-Analysis.<p>Objectives: This meta-analysis compared the efficacy and safety of drug-coated balloon (DCB) angioplasty with drug-eluting stent (DES) for the treatment of de novo coronary artery disease.<h4>Methods</h4>Following PRISMA guidelines, we conducted a systematic search of major databases, including Cochrane, Medline, Embase and ClinicalTrials.gov, to identify eligible randomized controlled trials (RCTs) comparing DCB and DES. Mantel-Haenszel model was used for dichotomous outcomes. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model using RevMan software.<h4>Results</h4>Thirteen RCTs with a total of 4,686 patients were included. The analysis found no significant differences between DCB and DES for all-cause mortality (RR: 1.11, 95% CI: 0.81-1.52025-01-01T00:00:00Z20252026-06-06T16:54:06.724Z2025-08-27T03:10:15.698ZS-EPMC123035764058234810.1159/000547099