biostudies-literatureUnknown37(1)Smith L<h4>Objectives</h4>Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).<h4>Methods</h4>We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer's Association criteria were used to defAging clinical and experimental research235https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304052biostudies-literatureAssociation between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults.PMC12304052Soysal PSmith LTully MARichardson FKeyes HJacob LLopez Sanchez GFShin JIBarnett YKoyanagi AKostev KVeronese NRahmati MButler LfalseAssociation between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults.<h4>Objectives</h4>Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).<h4>Methods</h4>We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer's Association criteria were used to def2025-01-01T00:00:00Z2025 Jul2026-03-31T10:46:54.691Z2025-08-28T03:06:09.807ZS-EPMC123040524071982410.1007/s40520-025-03135-z