{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rothi MH"],"funding":["NIBIB NIH HHS","NIA NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)"],"pagination":["6944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304401"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m<sup>6,2</sup>A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. We demonstrate that DIMT-1 functions in the germline after mid-life to regulate lifespan. Depletion of dimt-1 leads to selective translation of transcripts important for stress resistance and lifespan regulation in the C. elegans germline including the cytochrome P450 daf-9, which synthesizes a st"],"journal":["Nature communications"],"pubmed_title":["The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life."],"pmcid":["PMC12304401"],"funding_grant_id":["R01 AG084739","R01AG084739","T32 EB016652","DP2 AG055947","R56 AG076496","R56AG076496"],"pubmed_authors":["Natale J","Dellacona S","Pohl N","Haddad JA","Rothi MH","Gladyshev VN","Greer EL","Sotomayor-Mena RG","Mitchell W","Sarkar GC","Ying K"],"additional_accession":[]},"is_claimable":false,"name":"The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life.","description":"Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m<sup>6,2</sup>A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. We demonstrate that DIMT-1 functions in the germline after mid-life to regulate lifespan. Depletion of dimt-1 leads to selective translation of transcripts important for stress resistance and lifespan regulation in the C. elegans germline including the cytochrome P450 daf-9, which synthesizes a st","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T15:56:53.056Z","creation":"2025-08-27T03:08:04.515Z"},"accession":"S-EPMC12304401","cross_references":{"pubmed":["40721431"],"doi":["10.1038/s41467-025-62323-7"]}}