{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin X"],"funding":["Project Program of National Clinical Research Center for Geriatric Disorders","Fonds de Recherche du Québec - Santé","National Natural Science Foundation of China","The Scientific Research Program of FuRong Laboratory","Fundamental Research Funds for the Central Universities of Central South University"],"pagination":["e70537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(7)"],"pubmed_abstract":["<h4>Aims</h4>This study aimed to characterize the topological changes in glucose metabolism covariance networks in amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>We assessed the interregional coordination of <sup>18</sup>F-FDG-PET data to examine topological alterations in individualized glucose metabolism covariance networks in 127 ALS patients compared to 128 healthy controls (HC).<h4>Results</h4>Compared to HC, ALS patients showed reduced small-worldness (lower normalized clustering coefficient, higher normalized characteristic path length) and decreased global and local efficiency, suggesting impaired global integration and local segregation. These network metrics correlated with disease progression and motor function. Regionally, altered degree centrality affected motor and defau"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis."],"pmcid":["PMC12304423"],"funding_grant_id":["U22A20377","2022LNJJ09","CB-C2022","2024ZZTS0954","2024PT5109"],"pubmed_authors":["Yi X","Jin X","Li J","Yuan P","Zhang J","Zhang H","Liu Q","Braden BB","Wu F","Wang J","Palaniyappan L","Zhang Y","Qiu T","Chen Y","Wang X","Grecucci A","Zheng D"],"additional_accession":[]},"is_claimable":false,"name":"Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.","description":"<h4>Aims</h4>This study aimed to characterize the topological changes in glucose metabolism covariance networks in amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>We assessed the interregional coordination of <sup>18</sup>F-FDG-PET data to examine topological alterations in individualized glucose metabolism covariance networks in 127 ALS patients compared to 128 healthy controls (HC).<h4>Results</h4>Compared to HC, ALS patients showed reduced small-worldness (lower normalized clustering coefficient, higher normalized characteristic path length) and decreased global and local efficiency, suggesting impaired global integration and local segregation. These network metrics correlated with disease progression and motor function. Regionally, altered degree centrality affected motor and defau","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T17:11:01.619Z","creation":"2025-08-30T03:06:33.651Z"},"accession":"S-EPMC12304423","cross_references":{"pubmed":["40726139"],"doi":["10.1111/cns.70537"]}}