biostudies-literatureLi Lthe National Key Plan for Scientific Research and Development of Chinathe Technology Major Project of Hunan Provincial Science and Technology DepartmentNational Key Research and Development Program of Chinae70549https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304428biostudies-literatureUnknown31(7)<h4>Aims</h4>The study aimed to investigate the role of NUS1 variants in Parkinson's disease (PD) progression and evaluate plasma Nogo-B receptor (NgBR) as a potential biomarker.<h4>Methods</h4>We recruited 228 PD patients, including 38 with NUS1 variants (NUS1-PD) and 190 without (GU-PD), and all underwent at least two follow-up visits. Linear mixed-effects models assessed motor and non-motor symptom progression. Plasma NgBR levels were measured in PD, Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), and healthy controls (HC), and receiver operating characteristic curve analysis evaluated its diagnostic efficacy.<h4>Results</h4>NUS1-PD demonstrated an earlier age at onset and more severe motor features than GU-PD at baseline. Longitudinal analyses showed similar progreCNS neuroscience & therapeuticsThe Progression of NUS1-Associated Parkinson's Disease and the Diagnostic Potential of Plasma NgBR.PMC123044282021SK10102021YFC25012042021YFC2502100Liu ZLi JGuo JHuang JSun QZhang XXu QXiang YTang BLi LYan XfalseThe Progression of NUS1-Associated Parkinson's Disease and the Diagnostic Potential of Plasma NgBR.<h4>Aims</h4>The study aimed to investigate the role of NUS1 variants in Parkinson's disease (PD) progression and evaluate plasma Nogo-B receptor (NgBR) as a potential biomarker.<h4>Methods</h4>We recruited 228 PD patients, including 38 with NUS1 variants (NUS1-PD) and 190 without (GU-PD), and all underwent at least two follow-up visits. Linear mixed-effects models assessed motor and non-motor symptom progression. Plasma NgBR levels were measured in PD, Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), and healthy controls (HC), and receiver operating characteristic curve analysis evaluated its diagnostic efficacy.<h4>Results</h4>NUS1-PD demonstrated an earlier age at onset and more severe motor features than GU-PD at baseline. Longitudinal analyses showed similar progre2025-01-01T00:00:00Z2025 Jul2026-03-31T10:46:01.774Z2025-08-30T03:04:54.669ZS-EPMC123044284072611410.1111/cns.70549