biostudies-literatureSvestkova AMinisterstvo Školství, Mládeže a Tělovýchovy20552076251360973https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304636biostudies-literatureUnknown11<h4>Objective</h4>Generative AI is increasingly used to provide health-related information in addition to online health information seeking (OHIS). Users' willingness to adopt it is crucial. This study investigates individual factors associated with more frequent OHIS: health status, health anxiety, and eHealth literacy. Using the Technology Acceptance Model (TAM), we examined whether these factors are related to more trust in generative AI for health-related purposes and the willingness to use it.<h4>Methods</h4>Using SEM, we analyzed cross-sectional survey data (<i>N</i> = 4775) that is representative of adult Czech internet users (50% female; aged 18-95 years).<h4>Results</h4>Trust in AI was strongly associated with willingness to use AI. Health status and health anxiety were related toDigital healthFactors that influence trust and willingness to use generative AI for health information: A cross-sectional study.PMC12304636LX22NPO5101Svestkova AHuang YSmahel DfalseFactors that influence trust and willingness to use generative AI for health information: A cross-sectional study.<h4>Objective</h4>Generative AI is increasingly used to provide health-related information in addition to online health information seeking (OHIS). Users' willingness to adopt it is crucial. This study investigates individual factors associated with more frequent OHIS: health status, health anxiety, and eHealth literacy. Using the Technology Acceptance Model (TAM), we examined whether these factors are related to more trust in generative AI for health-related purposes and the willingness to use it.<h4>Methods</h4>Using SEM, we analyzed cross-sectional survey data (<i>N</i> = 4775) that is representative of adult Czech internet users (50% female; aged 18-95 years).<h4>Results</h4>Trust in AI was strongly associated with willingness to use AI. Health status and health anxiety were related to2025-01-01T00:00:00Z2025 Jan-Dec2026-06-06T13:40:10.014Z2025-08-30T03:06:16.854ZS-EPMC123046364073554310.1177/20552076251360973