{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Summers DM"],"funding":["National Institute for Health Research (NIHR)","Newcastle University","National Institute for Health and Care Research","University of Cambridge"],"pagination":["101390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12304751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56"],"pubmed_abstract":["<h4>Background</h4>Pre-implantation biopsy may help select kidneys retrieved from elderly deceased donors for transplantation, but concerns persist that it may cause unnecessary discard of kidneys that would have provided acceptable transplant function. The PITHIA trial tested the hypothesis that introduction of a National Digital Pathology Service (NDPS) would increase the proportion of kidneys transplanted from elderly donors and/or improve their function.<h4>Methods</h4>A stepped-wedge cluster randomised controlled registry trial delivered the NDPS to 22 UK kidney transplant centres (clusters) in 5 sequences at four-monthly intervals, using a restricted randomisation technique to ensure similar cluster sizes in the intervention and control status. Upon access to the intervention, centre"],"journal":["The Lancet regional health. Europe"],"pubmed_title":["Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial); a stepped-wedge cluster randomised registry trial."],"pmcid":["PMC12304751"],"funding_grant_id":["NIHR203332","PB-PG-1215-20033"],"pubmed_authors":["Pettigrew GJ","Callaghan CJ","Moinuddin Z","Thiru S","Ghazanfar A","Brearley N","McDaid J","Mehew J","Chatzitolios A","Paterson A","Motallebzadeh R","Barlow A","Simmonds N","Hill H","Hunter J","Bagul A","Terrace J","Dutta S","Bardsley V","Boffa C","Hemming K","Perera R","Connor A","Szabo L","Johnson RJ","Mark P","Shrestha B","Sidders A","Dor FJMF","Ayorinde JOO","Jarvis R","Griffiths MH","Laing E","Marson L","Stevenson K","Jones G","Roufosse C","Ridgway D","Thomas H","Cain O","Knight S","Sheaff M","Roy D","Neil DA","Gopalakrishnan K","Turner S","Vydianath B","Saif I","Sharif A","Torpey N","Fotheringham J","Phillips S","Deary AJ","Smith L","Wilson C","Summers DM","Gibbs P","Sivaprakasam R","Brown R","Baker R"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial); a stepped-wedge cluster randomised registry trial.","description":"<h4>Background</h4>Pre-implantation biopsy may help select kidneys retrieved from elderly deceased donors for transplantation, but concerns persist that it may cause unnecessary discard of kidneys that would have provided acceptable transplant function. The PITHIA trial tested the hypothesis that introduction of a National Digital Pathology Service (NDPS) would increase the proportion of kidneys transplanted from elderly donors and/or improve their function.<h4>Methods</h4>A stepped-wedge cluster randomised controlled registry trial delivered the NDPS to 22 UK kidney transplant centres (clusters) in 5 sequences at four-monthly intervals, using a restricted randomisation technique to ensure similar cluster sizes in the intervention and control status. Upon access to the intervention, centre","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-06T13:40:04.092Z","creation":"2025-08-28T03:09:50.799Z"},"accession":"S-EPMC12304751","cross_references":{"pubmed":["40735376"],"doi":["10.1016/j.lanepe.2025.101390"]}}