biostudies-literatureUnknown27(1)Zafar S<h4>Background</h4>Missense single-nucleotide polymorphisms (SNPs) in various genetic pathways can lead to the development of breast cancer. Protein kinase C delta (PRKCD) is involved in various important cellular pathways, and its altered expression has been identified in different cancers. Genetic alteration in this gene can be involved in cancer onset and progression. To date, there are no studies performed to elucidate the role of PRKCD missense variants in the development of breast cancer. Therefore, this study aims to identify the association of pathogenic missense SNPs in PRKCD with breast cancer.<h4>Methods</h4>The missense variants of PRKCD were retrieved from the Ensembl and dbSNP databases. Missense variants were analysed through various computational tools, and four variants ofBreast cancer research : BCR139https://www.ebi.ac.uk/biostudies/studies/S-EPMC12305980biostudies-literatureMissense variants in PRKCD: elucidating their potential association with breast cancer.PMC12305980Badshah YZafar SRazak SHusain FMAfsar TTrembley JHShabbir MMussarat ULatif AfalseMissense variants in PRKCD: elucidating their potential association with breast cancer.<h4>Background</h4>Missense single-nucleotide polymorphisms (SNPs) in various genetic pathways can lead to the development of breast cancer. Protein kinase C delta (PRKCD) is involved in various important cellular pathways, and its altered expression has been identified in different cancers. Genetic alteration in this gene can be involved in cancer onset and progression. To date, there are no studies performed to elucidate the role of PRKCD missense variants in the development of breast cancer. Therefore, this study aims to identify the association of pathogenic missense SNPs in PRKCD with breast cancer.<h4>Methods</h4>The missense variants of PRKCD were retrieved from the Ensembl and dbSNP databases. Missense variants were analysed through various computational tools, and four variants of2025-01-01T00:00:00Z2025 Jul2026-03-31T11:04:54.26Z2025-08-27T03:11:20.458ZS-EPMC123059804072218210.1186/s13058-025-02090-x