{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(7)"],"submitter":["Sui CF"],"pubmed_abstract":["IntroductionPrediabetes (PD), defined by impaired glucose tolerance or impaired fasting glucose, represents a growing global health challenge, with a prevalence projected to increase substantially. PD is a critical intervention target because of its high annual progression rate (5-10%) to type 2 diabetes mellitus (T2DM) and elevated cardiovascular disease (CVD) risk. Non-surgical interventions (NSIs), particularly lifestyle modifications (LMs) and pharmacological therapies, are the cornerstone of PD management, demonstrating efficacy and cost efficiency over surgical options. However, despite LM's ability to reduce T2DM incidence by 40-70% in trials such as the Diabetes Prevention Program, real-world implementation faces barriers, including resource intensity and complex delivery requireme"],"journal":["BMJ open"],"pagination":["e093768"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12306239"],"repository":["biostudies-literature"],"pubmed_title":["Systematic review protocol for effectiveness and cost-effectiveness of non-surgical interventions to prevent diabetes progression in adults with prediabetes."],"pmcid":["PMC12306239"],"pubmed_authors":["Soh YC","Al-Worafi YM","Ng CH","Ming LC","Hussain Z","Sui CF"],"additional_accession":[]},"is_claimable":false,"name":"Systematic review protocol for effectiveness and cost-effectiveness of non-surgical interventions to prevent diabetes progression in adults with prediabetes.","description":"IntroductionPrediabetes (PD), defined by impaired glucose tolerance or impaired fasting glucose, represents a growing global health challenge, with a prevalence projected to increase substantially. PD is a critical intervention target because of its high annual progression rate (5-10%) to type 2 diabetes mellitus (T2DM) and elevated cardiovascular disease (CVD) risk. Non-surgical interventions (NSIs), particularly lifestyle modifications (LMs) and pharmacological therapies, are the cornerstone of PD management, demonstrating efficacy and cost efficiency over surgical options. However, despite LM's ability to reduce T2DM incidence by 40-70% in trials such as the Diabetes Prevention Program, real-world implementation faces barriers, including resource intensity and complex delivery requireme","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T17:09:10.258Z","creation":"2025-08-30T03:06:19.721Z"},"accession":"S-EPMC12306239","cross_references":{"pubmed":["40701593"],"doi":["10.1136/bmjopen-2024-093768"]}}