{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Weisinger J"],"pubmed_abstract":["<h4>Objective</h4>The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised.<h4>Methods</h4>We compared the clinical presentation and the outcome of patients with iTTP with coexistent SLE (SLE-iTTP) to an age-sex matched cohort of patients with idiopathic iTTP without SLE.<h4>Results</h4>During the study period, 1409 patients with iTTP were recruited in our registry. Of these, 79 (6%) had a prior or concurrent diagnosis of SLE at the time of iTTP diagnosis, and 437 (31%) had detectable ANAs without other clinical features of SLE. When compared with idiopathic iTTP, patients with SLE-iTTP had more severe renal involvement, and cardiac involvement was more prevalent, w"],"journal":["Lupus science & medicine"],"pagination":["e001691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12306328"],"repository":["biostudies-literature"],"pubmed_title":["Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome."],"pmcid":["PMC12306328"],"pubmed_authors":["Choukroun G","Poullin P","Weisinger J","Veyradier A","Bouzid R","Fadlallah J","Dana R","Delmas Y","Provot F","Rieu V","Coppo P","Benhamou Y","Marie M","Le Guern V","Chantepie S","Ribes D","Martis N","Joly BS"],"additional_accession":[]},"is_claimable":false,"name":"Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome.","description":"<h4>Objective</h4>The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised.<h4>Methods</h4>We compared the clinical presentation and the outcome of patients with iTTP with coexistent SLE (SLE-iTTP) to an age-sex matched cohort of patients with idiopathic iTTP without SLE.<h4>Results</h4>During the study period, 1409 patients with iTTP were recruited in our registry. Of these, 79 (6%) had a prior or concurrent diagnosis of SLE at the time of iTTP diagnosis, and 437 (31%) had detectable ANAs without other clinical features of SLE. When compared with idiopathic iTTP, patients with SLE-iTTP had more severe renal involvement, and cardiac involvement was more prevalent, w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T11:03:52.602Z","creation":"2025-08-27T03:11:12.579Z"},"accession":"S-EPMC12306328","cross_references":{"pubmed":["40730415"],"doi":["10.1136/lupus-2025-001691"]}}