biostudies-literatureUnknown12(2)Weisinger J<h4>Objective</h4>The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised.<h4>Methods</h4>We compared the clinical presentation and the outcome of patients with iTTP with coexistent SLE (SLE-iTTP) to an age-sex matched cohort of patients with idiopathic iTTP without SLE.<h4>Results</h4>During the study period, 1409 patients with iTTP were recruited in our registry. Of these, 79 (6%) had a prior or concurrent diagnosis of SLE at the time of iTTP diagnosis, and 437 (31%) had detectable ANAs without other clinical features of SLE. When compared with idiopathic iTTP, patients with SLE-iTTP had more severe renal involvement, and cardiac involvement was more prevalent, wLupus science & medicinee001691https://www.ebi.ac.uk/biostudies/studies/S-EPMC12306328biostudies-literatureImmune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome.PMC12306328Choukroun GPoullin PWeisinger JVeyradier ABouzid RFadlallah JDana RDelmas YProvot FRieu VCoppo PBenhamou YMarie MLe Guern VChantepie SRibes DMartis NJoly BSfalseImmune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome.<h4>Objective</h4>The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised.<h4>Methods</h4>We compared the clinical presentation and the outcome of patients with iTTP with coexistent SLE (SLE-iTTP) to an age-sex matched cohort of patients with idiopathic iTTP without SLE.<h4>Results</h4>During the study period, 1409 patients with iTTP were recruited in our registry. Of these, 79 (6%) had a prior or concurrent diagnosis of SLE at the time of iTTP diagnosis, and 437 (31%) had detectable ANAs without other clinical features of SLE. When compared with idiopathic iTTP, patients with SLE-iTTP had more severe renal involvement, and cardiac involvement was more prevalent, w2025-01-01T00:00:00Z2025 Jul2026-03-31T11:03:52.602Z2025-08-27T03:11:12.579ZS-EPMC123063284073041510.1136/lupus-2025-001691