{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi Y"],"funding":["Guangdong Medical Science and Technology Research Fund Project","Guangzhou Health Science and Technology Project"],"pagination":["27613"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12307690"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2's oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2's serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment."],"journal":["Scientific reports"],"pubmed_title":["The value of acetylation reader YEATS2 in hepatocellular carcinoma management."],"pmcid":["PMC12307690"],"funding_grant_id":["B2023049","A2023165","20251A011074","20251A011073"],"pubmed_authors":["Huang S","Zhou Q","Xiao W","Jia H","Chen Y","Kang J","Shi Y","Xiao Q"],"additional_accession":[]},"is_claimable":false,"name":"The value of acetylation reader YEATS2 in hepatocellular carcinoma management.","description":"Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2's oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2's serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-17T15:50:05.4Z","creation":"2025-08-17T03:06:20.353Z"},"accession":"S-EPMC12307690","cross_references":{"pubmed":["40731114"],"doi":["10.1038/s41598-025-09945-5"]}}