biostudies-literatureShi YGuangdong Medical Science and Technology Research Fund ProjectGuangzhou Health Science and Technology Project27613https://www.ebi.ac.uk/biostudies/studies/S-EPMC12307690biostudies-literatureUnknown15(1)Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2's oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2's serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.Scientific reportsThe value of acetylation reader YEATS2 in hepatocellular carcinoma management.PMC12307690B2023049A202316520251A01107420251A011073Huang SZhou QXiao WJia HChen YKang JShi YXiao QfalseThe value of acetylation reader YEATS2 in hepatocellular carcinoma management.Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2's oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2's serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.2025-01-01T00:00:00Z2025 Jul2026-03-17T15:50:05.4Z2025-08-17T03:06:20.353ZS-EPMC123076904073111410.1038/s41598-025-09945-5