biostudies-literatureUnknown21(5)Mendel B<h4>Background</h4>Patent Ductus Arteriosus (PDA) is a common condition in premature infants requiring intervention to avoid problems. Despite improvements in lowering radiation exposure and employing better contrast agents, fluoroscopy is still the most widely employed technique, which exposes interventional echocardiographers to radiation risks. Techniques, such as Transthoracic Echocardiography (TTE)-guided procedures or Transesophageal Echocardiography (TEE)-guided procedures, provide radiationfree options. This systematic review and meta-analysis aimed to evaluate the safety and effectiveness of fluoroscopy-guided versus non-fluoroscopy-guided PDA closure techniques with respect to the reduction in procedural risks and improved clinical decision-making when treating hemodynamically seCurrent cardiology reviewse1573403X338573https://www.ebi.ac.uk/biostudies/studies/S-EPMC12308002biostudies-literatureSafety and Efficacy of Zero Fluoroscopy Patent Ductus Arteriosus Closure in Comparison to the Standardized Fluoroscopy-Guided Procedure: A Systematic Review and Meta-Analysis.PMC12308002Djiu RJNugroho AKZMendel BKohar KArifin KHWinarta JJagannatha GNPSiagian SNVidya APMumtaz MDEPrakoso RYumnanisha DAfalseSafety and Efficacy of Zero Fluoroscopy Patent Ductus Arteriosus Closure in Comparison to the Standardized Fluoroscopy-Guided Procedure: A Systematic Review and Meta-Analysis.<h4>Background</h4>Patent Ductus Arteriosus (PDA) is a common condition in premature infants requiring intervention to avoid problems. Despite improvements in lowering radiation exposure and employing better contrast agents, fluoroscopy is still the most widely employed technique, which exposes interventional echocardiographers to radiation risks. Techniques, such as Transthoracic Echocardiography (TTE)-guided procedures or Transesophageal Echocardiography (TEE)-guided procedures, provide radiationfree options. This systematic review and meta-analysis aimed to evaluate the safety and effectiveness of fluoroscopy-guided versus non-fluoroscopy-guided PDA closure techniques with respect to the reduction in procedural risks and improved clinical decision-making when treating hemodynamically se2025-01-01T00:00:00Z20252026-06-09T06:55:30.096Z2026-06-09T03:12:12.471ZS-EPMC123080023990168810.2174/011573403X338573241101092849