{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tian X"],"funding":["Haihe Laboratory of Sustainable Chemical Transformations","National Natural Science Foundation of China","State Key Laboratory of Chemical Oncogenomics","Shenzhen Bay Laboratory"],"pagination":["389-398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12308599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(7)"],"pubmed_abstract":["Organic singlet diradicaloids are promising photothermal agents owing to their exceptional light-harvesting capabilities and efficient light-to-heat conversion. In this study, two stable dibenzononazethrene isomers, DBNZ1 and DBNZ2, are synthesized through a concise method and isolated in crystalline form. An open-shell singlet diradical ground state, with diradical indices of 0.67 and 0.69, is confirmed through a combination of theoretical and experimental approaches. Steady-state and time-resolved absorption spectroscopy demonstrated efficient light absorption in the far-red region and excellent light-to-heat conversion, attributed to a rapid nonradiative process. Encapsulation of DBNZ1 with an amphiphilic polymer produced water-dispersible nanoparticles (DBNZ1-NPs) with enhanced stability, achieving an impressive photothermal conversion efficiency of 72.9%. An <i>in vitro</i> photothermal therapy study demonstrated that DBNZ1-NPs functioned as biocompatible tumor ablation agents when activated by an 808 nm laser, highlighting their potential application in cancer photothermal therapy."],"journal":["Precision chemistry"],"pubmed_title":["Dibenzononazethrene Isomers: Stable Singlet Diradicaloids with Efficient Photothermal Conversion."],"pmcid":["PMC12308599"],"funding_grant_id":["22222110","24HHWCSS00009","22371206"],"pubmed_authors":["Wang M","Ye L","Lv M","Ma L","Tian X","Gao Y","Ma X","Yu G","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"Dibenzononazethrene Isomers: Stable Singlet Diradicaloids with Efficient Photothermal Conversion.","description":"Organic singlet diradicaloids are promising photothermal agents owing to their exceptional light-harvesting capabilities and efficient light-to-heat conversion. In this study, two stable dibenzononazethrene isomers, DBNZ1 and DBNZ2, are synthesized through a concise method and isolated in crystalline form. An open-shell singlet diradical ground state, with diradical indices of 0.67 and 0.69, is confirmed through a combination of theoretical and experimental approaches. Steady-state and time-resolved absorption spectroscopy demonstrated efficient light absorption in the far-red region and excellent light-to-heat conversion, attributed to a rapid nonradiative process. Encapsulation of DBNZ1 with an amphiphilic polymer produced water-dispersible nanoparticles (DBNZ1-NPs) with enhanced stability, achieving an impressive photothermal conversion efficiency of 72.9%. An <i>in vitro</i> photothermal therapy study demonstrated that DBNZ1-NPs functioned as biocompatible tumor ablation agents when activated by an 808 nm laser, highlighting their potential application in cancer photothermal therapy.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T16:05:04.407Z","creation":"2025-08-27T03:06:37.58Z"},"accession":"S-EPMC12308599","cross_references":{"pubmed":["40746587"],"doi":["10.1021/prechem.5c00026"]}}