biostudies-literatureMu TOutstanding Scientific Fund of Shengjing HospitalNational Key Research and Development Program of China168https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309033biostudies-literatureUnknown18(1)<h4>Background</h4>SUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community. SUGT1 functions as a molecular chaperone, regulating the stability and activity of various proteins, while FH is a key enzyme in the tricarboxylic acid cycle, catalyzing the reversible conversion of fumarate to malate. Existing literature has established their essential roles in signaling, tumorigenesis, and cancer progression. However, their functions and mechanisms in ovarian cancer (OC) remain poorly understood.<h4>Results</h4>We found that high SUGT1 expression is associated with a more advanced FIGO stage in OC. SUGT1 knockdown significantly inhibits OC cell proliferation and metastasis, while its overexpression has the opJournal of ovarian researchMechanism by which SUGT1 downregulates FH to promote proliferation and migration in serous ovarian cancer.PMC12309033Grant No. 2017052018YFC1004203Wang MLiu YGeng DRui BYang YZhang YMu THe RRen BKuang ZfalseMechanism by which SUGT1 downregulates FH to promote proliferation and migration in serous ovarian cancer.<h4>Background</h4>SUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community. SUGT1 functions as a molecular chaperone, regulating the stability and activity of various proteins, while FH is a key enzyme in the tricarboxylic acid cycle, catalyzing the reversible conversion of fumarate to malate. Existing literature has established their essential roles in signaling, tumorigenesis, and cancer progression. However, their functions and mechanisms in ovarian cancer (OC) remain poorly understood.<h4>Results</h4>We found that high SUGT1 expression is associated with a more advanced FIGO stage in OC. SUGT1 knockdown significantly inhibits OC cell proliferation and metastasis, while its overexpression has the op2025-01-01T00:00:00Z2025 Jul2026-03-31T10:37:46.52Z2025-08-24T03:07:34.676ZS-EPMC123090334073136510.1186/s13048-025-01744-w