biostudies-literatureRen JShanghai municipal health commission&apos;s clinical research project in the health industryNational Natural Science Foundation of ChinaShanghai innovative medical device application demonstration projectShanghai municipal health commission's clinical research project in the health industryShanghai science and technology innovation action plan medical innovation research special project156https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309149biostudies-literatureUnknown14(1)<h4>Background</h4>Adolescent idiopathic scoliosis (AIS) is a prevalent spinal disorder, and the efficacy of conservative interventions for AIS remains unclear. This study aimed to identify the comparative efficacy of all available conservative interventions for AIS.<h4>Methods</h4>Nine databases were searched from their inception to February 2024 for randomized controlled trials comparing conservative interventions for AIS. Paired reviewers independently selected studies, assessed risk of bias, and assessed certainty of the evidence. Pairwise meta-analyses were performed by DerSimonian-Laird random-effects model. Network meta-analysis within the frequentist framework was conducted by R package netmeta, and network plots were generated by the network plot command in Stata.<h4>Results</h4>WSystematic reviewsComparative efficacy of conservative interventions for adolescent idiopathic scoliosis: a systematic review and network meta-analysis of randomized controlled trials.PMC123091492023401578237460723SHS0540023Y11920600Wen YKong LWen ZRen JWang SLin JFang MZhou XLi MfalseComparative efficacy of conservative interventions for adolescent idiopathic scoliosis: a systematic review and network meta-analysis of randomized controlled trials.<h4>Background</h4>Adolescent idiopathic scoliosis (AIS) is a prevalent spinal disorder, and the efficacy of conservative interventions for AIS remains unclear. This study aimed to identify the comparative efficacy of all available conservative interventions for AIS.<h4>Methods</h4>Nine databases were searched from their inception to February 2024 for randomized controlled trials comparing conservative interventions for AIS. Paired reviewers independently selected studies, assessed risk of bias, and assessed certainty of the evidence. Pairwise meta-analyses were performed by DerSimonian-Laird random-effects model. Network meta-analysis within the frequentist framework was conducted by R package netmeta, and network plots were generated by the network plot command in Stata.<h4>Results</h4>W2025-01-01T00:00:00Z2025 Jul2026-03-27T16:05:31.591Z2025-08-27T03:06:49.412ZS-EPMC123091494073952710.1186/s13643-025-02893-1