{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chatterjee J"],"funding":["Vision Restoration Initiative","National Institutes of Health","Schnuck Markets","NIH HHS"],"pagination":["1579-1593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309722"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(6)"],"pubmed_abstract":["<h4>Background</h4>The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this operates through immune cells, the underlying mechanisms remain unclear. Leveraging 2 well-characterized murine models of low-grade glioma occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.<h4>Methods</h4>Neurofibromatosis type 1 (Nf1)-mutant mice genetically engineered to develop optic pathway gliomas (Nf1OPG mice) by 3 months of age were reared under germ-free (GF) conditions, treated with specific cocktails of antibiotics, or given fecal matter transplants (FMTs). Intestinal microbial spe"],"journal":["Neuro-oncology"],"pubmed_title":["Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration."],"pmcid":["PMC12309722"],"funding_grant_id":["R35NS097211"],"pubmed_authors":["Chatterjee J","Schriefer LA","Aggarwal S","Campbell DE","Eligator T","Baldridge MT","Ouyang M","Li X","Gutmann DH","Qi X","Rodgers R","Mu R","Bozeman SL"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration.","description":"<h4>Background</h4>The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this operates through immune cells, the underlying mechanisms remain unclear. Leveraging 2 well-characterized murine models of low-grade glioma occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.<h4>Methods</h4>Neurofibromatosis type 1 (Nf1)-mutant mice genetically engineered to develop optic pathway gliomas (Nf1OPG mice) by 3 months of age were reared under germ-free (GF) conditions, treated with specific cocktails of antibiotics, or given fecal matter transplants (FMTs). Intestinal microbial spe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-06T22:33:28.928Z","creation":"2026-06-06T03:10:42.832Z"},"accession":"S-EPMC12309722","cross_references":{"pubmed":["39868555"],"doi":["10.1093/neuonc/noaf024"]}}