biostudies-literatureChatterjee JVision Restoration InitiativeNational Institutes of HealthSchnuck MarketsNIH HHS1579-1593https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309722biostudies-literatureUnknown27(6)<h4>Background</h4>The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this operates through immune cells, the underlying mechanisms remain unclear. Leveraging 2 well-characterized murine models of low-grade glioma occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.<h4>Methods</h4>Neurofibromatosis type 1 (Nf1)-mutant mice genetically engineered to develop optic pathway gliomas (Nf1OPG mice) by 3 months of age were reared under germ-free (GF) conditions, treated with specific cocktails of antibiotics, or given fecal matter transplants (FMTs). Intestinal microbial speNeuro-oncologyIntestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration.PMC12309722R35NS097211Chatterjee JSchriefer LAAggarwal SCampbell DEEligator TBaldridge MTOuyang MLi XGutmann DHQi XRodgers RMu RBozeman SLfalseIntestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration.<h4>Background</h4>The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this operates through immune cells, the underlying mechanisms remain unclear. Leveraging 2 well-characterized murine models of low-grade glioma occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.<h4>Methods</h4>Neurofibromatosis type 1 (Nf1)-mutant mice genetically engineered to develop optic pathway gliomas (Nf1OPG mice) by 3 months of age were reared under germ-free (GF) conditions, treated with specific cocktails of antibiotics, or given fecal matter transplants (FMTs). Intestinal microbial spe2025-01-01T00:00:00Z2025 Jul2026-06-06T22:33:28.928Z2026-06-06T03:10:42.832ZS-EPMC123097223986855510.1093/neuonc/noaf024