{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(8)"],"submitter":["Amrane K"],"pubmed_abstract":["<h4>Background</h4>Among the aggressive non-small-cell lung carcinoma subtypes, pulmonary sarcomatoid carcinoma (PSC) is a rare and poorly understood tumor. This study was undertaken to evaluate the efficacy [progression-free survival (PFS) and overall survival (OS)] of first-line immune checkpoint inhibitor (ICI) with or/without (±) chemotherapy (ChT) versus ChT alone against advanced PSCs (APSCs).<h4>Patients and methods</h4>Using the French Epidemiological Strategy and Medical Economics Lung Cancer (ESME-LC) database (2015-2022), we analyzed APSC patients' first-line ICI ± ChT or ChT outcomes, then applied propensity score weighting to indirectly compare them.<h4>Results</h4>Among 42 219 patients with untreated lung cancers, 229 (0.5%) had APSCs. One hundred and sixty-one (70.3%) received first-line treatment (43 ICI alone, 24 ICI + ChT, 94 ChT alone): median age, 66 years; 70.2% men; 69.8% Eastern Cooperative Oncology Group performance status 0/1, among 106 available values; 86.2% smokers or former smokers. Molecular testing was done for 113/161 (70.2%) patients, 35.4% of whom had a molecular abnormality, most frequently a KRAS mutation (39.7%). Programmed death-ligand 1 tumor proportion scores determined for 43.5% of tumors (70/161) were: 68.6% ≥50%, 8.6% 1%-49%, and 22.9% <1%. For the ICI ± ChT group, median PFS and OS were 4.6 months [95% confidence interval (CI) 2.1-8.2 months] and 20.6 months (95% CI 10.3-32.4 months), respectively. For ChT-alone recipients, median PFS and OS were 2.2 months (95% CI 2.0-3.0 months) and 6.8 months (95% CI 4.3-10.0 months), respectively. Applying a propensity score, ICI ± ChT was significantly associated with longer PFS (HR 0.46, 95% CI 0.29-0.72, P < 0.001) and longer OS (HR 0.46, 95% CI 0.28-0.74, P = 0.002) than ChT alone.<h4>Conclusion</h4>According to this real-world analysis, first-line ICI ± ChT seems to have considerably improved the prognosis of APSCs."],"journal":["ESMO open"],"pagination":["105343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309934"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of first-line treatments for advanced pulmonary sarcomatoid carcinomas: a real-world analysis."],"pmcid":["PMC12309934"],"pubmed_authors":["Perol M","Debieuvre D","Bosquet L","Guisier F","Schneider S","Ferrari V","Girard N","Lena H","Descourt R","Dansin E","Bigot F","Chouaid C","Quantin X","Madroszyk A","Bizieux A","Justeau G","Amrane K","Simoneau Y","Cabarrou B","Falchero L"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of first-line treatments for advanced pulmonary sarcomatoid carcinomas: a real-world analysis.","description":"<h4>Background</h4>Among the aggressive non-small-cell lung carcinoma subtypes, pulmonary sarcomatoid carcinoma (PSC) is a rare and poorly understood tumor. This study was undertaken to evaluate the efficacy [progression-free survival (PFS) and overall survival (OS)] of first-line immune checkpoint inhibitor (ICI) with or/without (±) chemotherapy (ChT) versus ChT alone against advanced PSCs (APSCs).<h4>Patients and methods</h4>Using the French Epidemiological Strategy and Medical Economics Lung Cancer (ESME-LC) database (2015-2022), we analyzed APSC patients' first-line ICI ± ChT or ChT outcomes, then applied propensity score weighting to indirectly compare them.<h4>Results</h4>Among 42 219 patients with untreated lung cancers, 229 (0.5%) had APSCs. One hundred and sixty-one (70.3%) received first-line treatment (43 ICI alone, 24 ICI + ChT, 94 ChT alone): median age, 66 years; 70.2% men; 69.8% Eastern Cooperative Oncology Group performance status 0/1, among 106 available values; 86.2% smokers or former smokers. Molecular testing was done for 113/161 (70.2%) patients, 35.4% of whom had a molecular abnormality, most frequently a KRAS mutation (39.7%). Programmed death-ligand 1 tumor proportion scores determined for 43.5% of tumors (70/161) were: 68.6% ≥50%, 8.6% 1%-49%, and 22.9% <1%. For the ICI ± ChT group, median PFS and OS were 4.6 months [95% confidence interval (CI) 2.1-8.2 months] and 20.6 months (95% CI 10.3-32.4 months), respectively. For ChT-alone recipients, median PFS and OS were 2.2 months (95% CI 2.0-3.0 months) and 6.8 months (95% CI 4.3-10.0 months), respectively. Applying a propensity score, ICI ± ChT was significantly associated with longer PFS (HR 0.46, 95% CI 0.29-0.72, P < 0.001) and longer OS (HR 0.46, 95% CI 0.28-0.74, P = 0.002) than ChT alone.<h4>Conclusion</h4>According to this real-world analysis, first-line ICI ± ChT seems to have considerably improved the prognosis of APSCs.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T10:37:46.094Z","creation":"2025-08-24T03:07:27.132Z"},"accession":"S-EPMC12309934","cross_references":{"pubmed":["40706224"],"doi":["10.1016/j.esmoop.2025.105343"]}}