biostudies-literatureUnknown7(8)Leon SJ<h4>Rationale & objective</h4>Gender-affirming hormone therapy (GAHT) modifies lean body mass and body fat but its impact on kidney function is uncertain. We sought to evaluate the association of GAHT with kidney function and clinical outcomes.<h4>Study design</h4>A retrospective observational cohort study using linked health administrative databases.<h4>Setting & participants</h4>Transgender and gender diverse (TGD) adults in Manitoba, Canada from January 1, 2007, to March 31, 2018.<h4>Exposure</h4>GAHT or no GAHT prescriptions.<h4>Outcomes</h4>The primary outcome was the change in serum creatinine levels. Secondary outcomes included the change in urine albumin-to-creatinine ratio, incident acute kidney injury, chronic kidney disease, and hypertension.<h4>Analytical approach</h4>Outcomes Kidney medicine101051https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309945biostudies-literatureGender-affirming Hormone Therapy and Changes in Kidney Function in Adults: A Retrospective Population-based Study.PMC12309945Williams LCollister DRigatto CAhmad TFung RBondaz LHundemer GLChristie EWhite CSaad NSidhu BAhmed SBDruce ITangri NDahl MLevin ARogers ATennankore KBurgess AFerguson TWWald RMoncrieff KKomenda PJablonski TBohm CBond RGAHT-KIDNEY InvestigatorsLeon SJNadeau-Fredette ACWhitlock RfalseGender-affirming Hormone Therapy and Changes in Kidney Function in Adults: A Retrospective Population-based Study.<h4>Rationale & objective</h4>Gender-affirming hormone therapy (GAHT) modifies lean body mass and body fat but its impact on kidney function is uncertain. We sought to evaluate the association of GAHT with kidney function and clinical outcomes.<h4>Study design</h4>A retrospective observational cohort study using linked health administrative databases.<h4>Setting & participants</h4>Transgender and gender diverse (TGD) adults in Manitoba, Canada from January 1, 2007, to March 31, 2018.<h4>Exposure</h4>GAHT or no GAHT prescriptions.<h4>Outcomes</h4>The primary outcome was the change in serum creatinine levels. Secondary outcomes included the change in urine albumin-to-creatinine ratio, incident acute kidney injury, chronic kidney disease, and hypertension.<h4>Analytical approach</h4>Outcomes 2025-01-01T00:00:00Z2025 Aug2026-03-27T15:29:41.793Z2025-08-24T03:07:22.824ZS-EPMC123099454074072910.1016/j.xkme.2025.101051