{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(8)"],"submitter":["Manamela NP"],"pubmed_abstract":["In addition to neutralization, Fc effector function contributes to vaccine-mediated protection against severe SARS-CoV-2 infection. However, differential coordination and cross-reactivity of Fc effector functions across vaccines is not clearly defined. A secondary analysis of three vaccines with BNT162b2, Ad26.CoV2.S (NCT04838795), and ChAdOx1 nCoV-19 (NCT04444674) reveals that BNT162b2 elicits the highest levels of binding, neutralization, and Fc effector function with antibody-dependent cellular cytotoxicity (ADCC), phagocytosis (ADCP), and complement deposition (ADCD) significantly differing by vaccine modality. Ad26.CoV2.S showed low ADCD activity before a homologous boost, which significantly increased this function. BNT162b2 vaccination triggered higher levels of cross-reactive neutr"],"journal":["iScience"],"pagination":["113084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12309960"],"repository":["biostudies-literature"],"pubmed_title":["SARS-CoV-2 vaccines elicit differential Fc effector functions."],"pmcid":["PMC12309960"],"pubmed_authors":["Mzindle N","Hermanus T","Ayres F","Gray GG","Richardson SI","Motsoeneng BM","Moore PL","Spencer H","Makhado Z","Serage R","Manamela NP","Madhi SA","Bekker LG"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 vaccines elicit differential Fc effector functions.","description":"In addition to neutralization, Fc effector function contributes to vaccine-mediated protection against severe SARS-CoV-2 infection. However, differential coordination and cross-reactivity of Fc effector functions across vaccines is not clearly defined. A secondary analysis of three vaccines with BNT162b2, Ad26.CoV2.S (NCT04838795), and ChAdOx1 nCoV-19 (NCT04444674) reveals that BNT162b2 elicits the highest levels of binding, neutralization, and Fc effector function with antibody-dependent cellular cytotoxicity (ADCC), phagocytosis (ADCP), and complement deposition (ADCD) significantly differing by vaccine modality. Ad26.CoV2.S showed low ADCD activity before a homologous boost, which significantly increased this function. BNT162b2 vaccination triggered higher levels of cross-reactive neutr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-16T05:52:20.535Z","creation":"2025-08-14T03:06:18.836Z"},"accession":"S-EPMC12309960","cross_references":{"pubmed":["40740485"],"doi":["10.1016/j.isci.2025.113084"]}}