biostudies-literatureUnknown15Xu S<h4>Objective</h4>This study aimed to investigate hepatitis B virus (HBV) reactivation and its impact on postoperative survival in patients with HBV-related hepatocellular carcinoma (HCC) who underwent conversion therapy. The therapeutic regimen consisted of interventional procedures (hepatic artery infusion chemotherapy [HAIC] and/or transarterial chemoembolization [TACE]) combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs).<h4>Methods</h4>A retrospective analysis was performed at a single institution involving 91 patients <i>who had</i> initially unresectable HCC linked to the hepatitis B virus. These patients achieved resectability following conversion therapy and subsequently underwent surgical tumor removal. Logistic regression identified risk factoFrontiers in cellular and infection microbiology1598193https://www.ebi.ac.uk/biostudies/studies/S-EPMC12310596biostudies-literaturePostoperative hepatitis B virus reactivation and its impact on survival in HBV-related hepatocellular carcinoma patients undergoing conversion therapy with interventional therapy combined with tyrosine kinase inhibitors and immune checkpoint inhibitors.PMC12310596Yuan DWei MBai TTang ZPang QXu SWang XLiu DWu FfalsePostoperative hepatitis B virus reactivation and its impact on survival in HBV-related hepatocellular carcinoma patients undergoing conversion therapy with interventional therapy combined with tyrosine kinase inhibitors and immune checkpoint inhibitors.<h4>Objective</h4>This study aimed to investigate hepatitis B virus (HBV) reactivation and its impact on postoperative survival in patients with HBV-related hepatocellular carcinoma (HCC) who underwent conversion therapy. The therapeutic regimen consisted of interventional procedures (hepatic artery infusion chemotherapy [HAIC] and/or transarterial chemoembolization [TACE]) combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs).<h4>Methods</h4>A retrospective analysis was performed at a single institution involving 91 patients <i>who had</i> initially unresectable HCC linked to the hepatitis B virus. These patients achieved resectability following conversion therapy and subsequently underwent surgical tumor removal. Logistic regression identified risk facto2025-01-01T00:00:00Z20252026-03-18T13:31:38.184Z2025-08-18T09:54:03.347ZS-EPMC123105964074695710.3389/fcimb.2025.1598193