{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Reichelt-Wurm S"],"funding":["Universitätsklinikum Regensburg"],"pubmed_abstract":["The hypoxia-inducible factor 1α (Hif1α) represents the master transcription factor coordinating cellular responses to oxygen depletion. With hundreds of target genes it plays a key role in numerous bio-medical conditions as well as neoplastic and non-cancerous diseases, which in turn requires a strict regulation. Long non-coding RNAs have the potential to virtually control every step of gene expression. We aimed to investigate the expression and role of HIF1A antisense lncRNAs HIF1A-AS1, AS2, and AS3 under hyperglycemic, hypoxic, or both conditions in three non-cancerous human renal cell types: HK-2 cells, primary RPTECs, and mesangial cells. We observed that HIF1A-AS2 and AS3 expression was upregulated under oxygen deprivation. Furthermore, knockdown (KD) of HIF1A-AS3 resulted in a signif"],"journal":["Scientific reports"],"pagination":["27876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12310967"],"repository":["biostudies-literature"],"pubmed_title":["Cell-type specific effects of the long non-coding RNA HIF1A-AS3 on HIF1A expression in kidney cells."],"pmcid":["PMC12310967"],"pubmed_authors":["Kretz M","Reichelt-Wurm S","Knauss L","Eggenhofer E","Scharf M","Strasser B","Holler K","Banas B","Banas MC"],"additional_accession":[]},"is_claimable":false,"name":"Cell-type specific effects of the long non-coding RNA HIF1A-AS3 on HIF1A expression in kidney cells.","description":"The hypoxia-inducible factor 1α (Hif1α) represents the master transcription factor coordinating cellular responses to oxygen depletion. With hundreds of target genes it plays a key role in numerous bio-medical conditions as well as neoplastic and non-cancerous diseases, which in turn requires a strict regulation. Long non-coding RNAs have the potential to virtually control every step of gene expression. We aimed to investigate the expression and role of HIF1A antisense lncRNAs HIF1A-AS1, AS2, and AS3 under hyperglycemic, hypoxic, or both conditions in three non-cancerous human renal cell types: HK-2 cells, primary RPTECs, and mesangial cells. We observed that HIF1A-AS2 and AS3 expression was upregulated under oxygen deprivation. Furthermore, knockdown (KD) of HIF1A-AS3 resulted in a signif","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T09:43:49.61Z","creation":"2025-08-16T03:07:07.942Z"},"accession":"S-EPMC12310967","cross_references":{"pubmed":["40739162"],"doi":["10.1038/s41598-025-12441-5"]}}