biostudies-literatureUnknown15Tomas A<h4>Introduction</h4>Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and progresses to advanced disease, highlighting the need for a deeper understanding of CM biology. Here, we describe the establishment and characterization of a novel patient-derived primary cell line, MelT79, developed from a metastatic lesion of a patient initially diagnosed with stage IB CM, who unexpectedly progressed to advanced disease.<h4>Methods</h4>MelT79 was characterized by multicolor fluorescence in situ hybridization, high resolution comparative genomic hybridization, and targeted next-generation sequencing. Gene and protein expression weFrontiers in oncology1531013https://www.ebi.ac.uk/biostudies/studies/S-EPMC12313697biostudies-literatureA novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma.PMC12313697Pojo MPereira PMFarricha VRosa JCTomas ARoque LMoura CGouveia EAlbuquerque CFrancisco ISilva ALCarvalho ECabral MGNunes HGarrido PMfalseA novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma.<h4>Introduction</h4>Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and progresses to advanced disease, highlighting the need for a deeper understanding of CM biology. Here, we describe the establishment and characterization of a novel patient-derived primary cell line, MelT79, developed from a metastatic lesion of a patient initially diagnosed with stage IB CM, who unexpectedly progressed to advanced disease.<h4>Methods</h4>MelT79 was characterized by multicolor fluorescence in situ hybridization, high resolution comparative genomic hybridization, and targeted next-generation sequencing. Gene and protein expression we2025-01-01T00:00:00Z20252026-04-12T15:24:47.713Z2026-04-07T13:17:37.537ZS-EPMC123136974075611610.3389/fonc.2025.1531013