biostudies-literatureFisher PBundesministerium f?r Bildung und ForschungUniversit?t Ulm11626-11631https://www.ebi.ac.uk/biostudies/studies/S-EPMC12314907biostudies-literatureUnknown25(30)High-resolution nanoscale nuclear magnetic resonance (NMR) allows measurement of chemical structure at the single-molecule level for determining molecular dynamics. Until now, nitrogen vacancy centers in diamond have been the only platform to demonstrate single-defect NMR sensing at sub-Hz spectral resolution. Using a single silicon vacancy defect prepared under CMOS-compatible conditions in commercial 4H-silicon carbide at room temperature, we use the Synchronized Readout technique to measure a test signal. We achieve a spectral resolution of 0.33 Hz, necessary for understanding molecular structure, and estimate a magnetic sensitivity of 358 μT/Hz for our system. We also explore the necessary improvements for achieving single-proton spin sensitivity. Combining these results with future inNano lettersHigh-Resolution Nanoscale AC Quantum Sensing in CMOS Compatible SiC.PMC1231490713N16296H1137/927115Fuhrmann JFisher PJelezko FHaylock BZappacosta ANagy RGao WCernansky RfalseHigh-Resolution Nanoscale AC Quantum Sensing in CMOS Compatible SiC.High-resolution nanoscale nuclear magnetic resonance (NMR) allows measurement of chemical structure at the single-molecule level for determining molecular dynamics. Until now, nitrogen vacancy centers in diamond have been the only platform to demonstrate single-defect NMR sensing at sub-Hz spectral resolution. Using a single silicon vacancy defect prepared under CMOS-compatible conditions in commercial 4H-silicon carbide at room temperature, we use the Synchronized Readout technique to measure a test signal. We achieve a spectral resolution of 0.33 Hz, necessary for understanding molecular structure, and estimate a magnetic sensitivity of 358 μT/Hz for our system. We also explore the necessary improvements for achieving single-proton spin sensitivity. Combining these results with future in2025-01-01T00:00:00Z2025 Jul2026-03-15T23:56:34.001Z2025-08-14T03:05:22.938ZS-EPMC123149074069356010.1021/acs.nanolett.5c02515