{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Couto B"],"funding":["Rossy Foundation","Canada Foundation for Innovation","Ontario Research Fund","Edmond J. Safra Philanthropic Foundation"],"pagination":["2650-2657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12316005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(8)"],"pubmed_abstract":["Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by four-repeat (4R) tau protein deposition. The substantia nigra (SN) and midbrain tegmentum nuclei (MBT) are consistently affected. Lymphocyte infiltrates are scarce in the brains of patients with neurodegenerative diseases, although a few reports have described their presence in the α-synucleinopathy Parkinson's disease (PD). To evaluate the cytotoxic T-cell response, serial sections spanning 120 μm of the SN were immunostained consecutively for phosphorylated tau (p-tau, AT8) or α-synuclein, cytotoxic T-cell marker and microglia marker HLA-DR. Sections were analysed with stereology software in 9 patients with PSP, 10 with PD and 6 healthy controls. We semiquantitatively scored CD8-positive cells in furthe"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy."],"pmcid":["PMC12316005"],"funding_grant_id":["40480"],"pubmed_authors":["Fox SH","Lee S","Li J","Couto B","Knott S","Fearon C","Tartaglia MC","Lang AE","Forrest SL","Kovacs GG"],"additional_accession":[]},"is_claimable":false,"name":"Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy.","description":"Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by four-repeat (4R) tau protein deposition. The substantia nigra (SN) and midbrain tegmentum nuclei (MBT) are consistently affected. Lymphocyte infiltrates are scarce in the brains of patients with neurodegenerative diseases, although a few reports have described their presence in the α-synucleinopathy Parkinson's disease (PD). To evaluate the cytotoxic T-cell response, serial sections spanning 120 μm of the SN were immunostained consecutively for phosphorylated tau (p-tau, AT8) or α-synuclein, cytotoxic T-cell marker and microglia marker HLA-DR. Sections were analysed with stereology software in 9 patients with PSP, 10 with PD and 6 healthy controls. We semiquantitatively scored CD8-positive cells in furthe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2025-08-12T03:05:10.821Z","creation":"2025-08-12T03:05:10.821Z"},"accession":"S-EPMC12316005","cross_references":{"pubmed":["40233181"],"doi":["10.1093/brain/awaf135"]}}