biostudies-literatureMarik THungarian Research NetworkMagyar Tudományos AkadémiaNemzeti Kutatási Fejlesztési és Innovációs Hivatal48https://www.ebi.ac.uk/biostudies/studies/S-EPMC12316631biostudies-literatureUnknown15(1)This study focuses on the peptaibiome produced by different species of Trichoderma belonging to clade Viride: T. koningii SZMC 28387 (CBS 979.70), T. cf. strigosellum SZMC 28007 (TUCIM 4886/IQ 191), T. cf. dorothopsis SZMC 28390 (TUCIM 416/TUB F-597), T. cf. strigosellum SZMC 28391 (TUCIM 423/DAOM 230018), T. atroviride SZMC 28748 (IMI 206040), T. hamatum SZMC 28747 (TUCIM 2730) and T. cf. dorothopsis SZMC 28005 (TUCIM 4882/IQ 11). We were able to identify new compounds with similarity to already known groups of peptaibiotics, as well as completely newly discovered compounds using high-performance liquid chromatography (HPLC) -mass spectrometry (MS). From the 367 peptaibiotics identified, 216 are peptaibols and 111 are lipopeptaibols. Out of all peptaibols, 55 are previously known, while 1Natural products and bioprospectingNovel peptaibiotics identified from Trichoderma clade Viride.PMC12316631HUN-REN 2001007KGYNK 2024EKÖP-24-4SZTE-629TKP2021-EGA-28EKÖP-24-4-SZTE-605Kocsube SSzekeres ADruzhinina ISTerna GKovacs FMarik TPapp TTyagi CVishwanathula ABalazs DGufu BVarga MRozsnyoi AVagvolgyi CKredics LfalseNovel peptaibiotics identified from Trichoderma clade Viride.This study focuses on the peptaibiome produced by different species of Trichoderma belonging to clade Viride: T. koningii SZMC 28387 (CBS 979.70), T. cf. strigosellum SZMC 28007 (TUCIM 4886/IQ 191), T. cf. dorothopsis SZMC 28390 (TUCIM 416/TUB F-597), T. cf. strigosellum SZMC 28391 (TUCIM 423/DAOM 230018), T. atroviride SZMC 28748 (IMI 206040), T. hamatum SZMC 28747 (TUCIM 2730) and T. cf. dorothopsis SZMC 28005 (TUCIM 4882/IQ 11). We were able to identify new compounds with similarity to already known groups of peptaibiotics, as well as completely newly discovered compounds using high-performance liquid chromatography (HPLC) -mass spectrometry (MS). From the 367 peptaibiotics identified, 216 are peptaibols and 111 are lipopeptaibols. Out of all peptaibols, 55 are previously known, while 12025-01-01T00:00:00Z2025 Aug2026-03-15T12:26:18.55Z2025-08-12T03:05:15.362ZS-EPMC123166314074841410.1007/s13659-025-00524-9