biostudies-literatureHe LNational Natural Science Foundation of China752https://www.ebi.ac.uk/biostudies/studies/S-EPMC12317606biostudies-literatureUnknown25(1)<h4>Background</h4>Growing data indicated that individuals diagnosed with major depressive disorder (MDD) had widespread inflammation, oxidative stress, and metabolic dysregulation. The objective of our study was to detect alterations in lipids of individuals with MDD, with the ultimate aim of developing potential biomarkers that may contribute to the diagnosis and treatment of MDD.<h4>Methods</h4>The current study was a single-center cross-sectional case-control design. Serum samples were obtained from 107 individuals diagnosed with MDD and 97 healthy controls (HC) aged 18 to 60 years. Lipidomics analysis was performed using an Ultimate 3000 UHPLC system coupled with a Q-Exactive HF MS platform. All data were processed using the specialized online software Metaboanalyst 5.0.<h4>Results</hBMC psychiatryLipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study.PMC1231760632300926Tao JLi JDuan NLiu LWang CMa XLiu QHe LShan RCao BWang LfalseLipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study.<h4>Background</h4>Growing data indicated that individuals diagnosed with major depressive disorder (MDD) had widespread inflammation, oxidative stress, and metabolic dysregulation. The objective of our study was to detect alterations in lipids of individuals with MDD, with the ultimate aim of developing potential biomarkers that may contribute to the diagnosis and treatment of MDD.<h4>Methods</h4>The current study was a single-center cross-sectional case-control design. Serum samples were obtained from 107 individuals diagnosed with MDD and 97 healthy controls (HC) aged 18 to 60 years. Lipidomics analysis was performed using an Ultimate 3000 UHPLC system coupled with a Q-Exactive HF MS platform. All data were processed using the specialized online software Metaboanalyst 5.0.<h4>Results</h2025-01-01T00:00:00Z2025 Aug2026-03-15T23:44:08.865Z2025-08-14T03:05:36.962ZS-EPMC123176064075113910.1186/s12888-025-07191-7