{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Soh WC"],"funding":["National Research Foundation of Korea (NRF)","National Cancer Center","National Cancer Center (NCC)","National Research Foundation of Korea"],"pagination":["e2505291122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12318239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(30)"],"pubmed_abstract":["Microvilli on T cells differ from those on epithelial cells, exhibiting filopodia-like characteristics that facilitate the clustering of molecules essential for sensing and cell migration. Recently, they have also been recognized as the structures from which T cell immunological synaptosomes (TIS) are released. In this study, we examined a key determinant of microvilli organization during T cell development and explored the functional roles of these structures, particularly in relation to T cell behaviors. During thymocyte maturation, single-positive thymocytes were found to develop more and longer microvilli than double-positive thymocytes. However, the deletion or inhibition of Cdc42, a small Rho family protein, significantly reduced both the number and length of microvilli in single-pos"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["<i>Cdc42</i> defect reveals insights into microvilli organization and function in T cell immunity."],"pmcid":["PMC12318239"],"funding_grant_id":["RS-2024-00419699","RS-2024-0034-0032","RS-2024-00341869","2022R1A2C4002627","NCC-2310600-3","2015R1A3A2066253"],"pubmed_authors":["Park SM","Lee S","Kim MS","Park J","Jun CD","Karabulut H","Kang HT","Soh WC","Kim HR","Park JS","Kang SK"],"additional_accession":[]},"is_claimable":false,"name":"<i>Cdc42</i> defect reveals insights into microvilli organization and function in T cell immunity.","description":"Microvilli on T cells differ from those on epithelial cells, exhibiting filopodia-like characteristics that facilitate the clustering of molecules essential for sensing and cell migration. Recently, they have also been recognized as the structures from which T cell immunological synaptosomes (TIS) are released. In this study, we examined a key determinant of microvilli organization during T cell development and explored the functional roles of these structures, particularly in relation to T cell behaviors. During thymocyte maturation, single-positive thymocytes were found to develop more and longer microvilli than double-positive thymocytes. However, the deletion or inhibition of Cdc42, a small Rho family protein, significantly reduced both the number and length of microvilli in single-pos","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-02T10:04:23.442Z","creation":"2025-08-12T03:04:28.439Z"},"accession":"S-EPMC12318239","cross_references":{"pubmed":["40711916"],"doi":["10.1073/pnas.2505291122"]}}