biostudies-literatureHosseini BHealth CanadaCanadian Institutes of Health Researche097134https://www.ebi.ac.uk/biostudies/studies/S-EPMC12320028biostudies-literatureUnknown15(8)<h4>Introduction</h4>SARS-CoV-2 is now endemic and expected to remain a health threat, with new variants continuing to emerge and the potential for vaccines to become less effective. While effective vaccines and natural immunity have significantly reduced hospitalisations and the need for critical care, outpatient treatment options remain limited, and real-world evidence on their clinical and cost-effectiveness is lacking. In this paper, we present the design of the Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID). By evaluating multiple treatment options in a pragmatic adaptive platform trial, this study will generate high-quality, generalisable evidence to inform clinical guidelines and healthcare decision-making.<h4>Methods and analysis</h4>BMJ openCanadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.PMC12320028PPE 190332FRN 183092Murthy SPersaud NRamsden VRMarshall JCPinto ADFowler RHudon CWarshafsky DBarber DButler CCLittle PSud ALeong CTarride JEMcBrien KLofters AWalji SMaclaren LWilchesky MDaley PSelby PMcCracken RLussier MTZelek BTelner DRac VEHulme JCondon ARayner JZarychanski RPaquette JSKeynan YSaxinger LMarshall EGGaries SPiszczek JUpshur REGSinger ABarrett BLogsetty SCrampton NLeBlanc ALee TCAndrew MSrivastava ADamji AJenkins DJAMoineddin RWong STda Costa BRAubrey-Bassler KWalsh RPark JJHMcDonald EGDahrouge SSpiwak ROrava BWood BGreiver MHosseini BJuni PSanchez-Ramirez DCIsenor JLall RMangin DShi HLother SfalseCanadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.<h4>Introduction</h4>SARS-CoV-2 is now endemic and expected to remain a health threat, with new variants continuing to emerge and the potential for vaccines to become less effective. While effective vaccines and natural immunity have significantly reduced hospitalisations and the need for critical care, outpatient treatment options remain limited, and real-world evidence on their clinical and cost-effectiveness is lacking. In this paper, we present the design of the Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID). By evaluating multiple treatment options in a pragmatic adaptive platform trial, this study will generate high-quality, generalisable evidence to inform clinical guidelines and healthcare decision-making.<h4>Methods and analysis</h4>2025-01-01T00:00:00Z2025 Aug2026-07-15T12:53:27.261Z2025-09-01T03:06:08.721ZS-EPMC123200284075432510.1136/bmjopen-2024-097134