biostudies-literatureUnknown54Hollosi NA<h4>Introduction</h4>Stereotactic radiosurgery (SRS) is a widely used treatment modality for vestibular schwannomas due to its non-invasive nature and high tumor control rates. However, some patients experience tumor progression after treatment. In this setting, reirradiation with SRS represents a potential treatment option. This systematic review and meta-analysis evaluates the evidence for reirradiation of vestibular schwannomas with SRS.<h4>Methods</h4>This systematic literature review and meta-analysis investigates the efficacy and safety of reirradiation with SRS for vestibular schwannoma and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).<h4>Results</h4>A total of 806 studies were screened and 35 included, comprising 394 reirraClinical and translational radiation oncology100989https://www.ebi.ac.uk/biostudies/studies/S-EPMC12320082biostudies-literatureReirradiation with stereotactic radiosurgery for vestibular schwannomas - a systematic review and meta-analysis.PMC12320082Shih HAVerhoeff JJCBruynzeel AMEMuacevic AHollosi NAEhret FSantacroce AFurweger CReimers JLKufeld MfalseReirradiation with stereotactic radiosurgery for vestibular schwannomas - a systematic review and meta-analysis.<h4>Introduction</h4>Stereotactic radiosurgery (SRS) is a widely used treatment modality for vestibular schwannomas due to its non-invasive nature and high tumor control rates. However, some patients experience tumor progression after treatment. In this setting, reirradiation with SRS represents a potential treatment option. This systematic review and meta-analysis evaluates the evidence for reirradiation of vestibular schwannomas with SRS.<h4>Methods</h4>This systematic literature review and meta-analysis investigates the efficacy and safety of reirradiation with SRS for vestibular schwannoma and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).<h4>Results</h4>A total of 806 studies were screened and 35 included, comprising 394 reirra2025-01-01T00:00:00Z2025 Sep2026-03-31T11:31:46.979Z2025-09-01T03:04:53.436ZS-EPMC123200824076129010.1016/j.ctro.2025.100989