biostudies-literatureUnknown3(2)Dussault J<h4>Background</h4>Human papillomavirus (HPV) infections cause several cancers, including nearly all cervical cancer cases. While there are safe and effective vaccines, the adolescent HPV vaccine coverage in France is low (<50%). Thus, we studied the effect of municipality-wide interventions to increase HPV vaccine uptake and intention among middle school students.<h4>Methods</h4>This cluster-randomised trial used an incomplete factorial design to arrange three components (in-school education, motivation, mobilisation (EMM); in-school vaccination; and local general practitioner (GP) trainings) into six intervention conditions, which were randomly assigned to 91 participating French municipalities. We assessed HPV vaccine status using online self-reported questionnaires that students (typicBMJ public healthe001007https://www.ebi.ac.uk/biostudies/studies/S-EPMC12320094biostudies-literatureEffect of a multicomponent HPV intervention on self-reported HPV vaccine uptake and intention among French adolescents and parents: results from the national, cluster-randomised PrevHPV trial.PMC12320094Partouche HGiraudeau BPrevHPV GroupZuo MBonmarin IEpaulard OBarret ASRossignol LThilly NSicsic JEcollan MTron AKalecinski JLasset CSimony MNekaa MAsse LMDVareilles GRaude JAilloud JBruel SAgrinier NBotelho-Nevers EJambon GDarlington EGagneux-Brunon AGilberg SBros JPinot JOudin Doglioni DCastagnet CGauchet ADussault JMichel MMueller JELevy-Bruhl DBel JLLe Duc-Banaszuk ASJeanleboeuf FJuneau CfalseEffect of a multicomponent HPV intervention on self-reported HPV vaccine uptake and intention among French adolescents and parents: results from the national, cluster-randomised PrevHPV trial.<h4>Background</h4>Human papillomavirus (HPV) infections cause several cancers, including nearly all cervical cancer cases. While there are safe and effective vaccines, the adolescent HPV vaccine coverage in France is low (<50%). Thus, we studied the effect of municipality-wide interventions to increase HPV vaccine uptake and intention among middle school students.<h4>Methods</h4>This cluster-randomised trial used an incomplete factorial design to arrange three components (in-school education, motivation, mobilisation (EMM); in-school vaccination; and local general practitioner (GP) trainings) into six intervention conditions, which were randomly assigned to 91 participating French municipalities. We assessed HPV vaccine status using online self-reported questionnaires that students (typic2025-01-01T00:00:00Z20252026-03-31T11:47:09.872Z2025-09-01T03:05:59.667ZS-EPMC123200944076136210.1136/bmjph-2024-001007