{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Edge RJ"],"funding":["National Centre for the Replacement, Refinement and Reduction of Animals in Research","Wellcome Trust"],"pagination":["e0013371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12321083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(8)"],"pubmed_abstract":["Snakebite is a significant public health concern in Africa, with the viperid species Echis ocellatus being responsible for the majority of snakebite deaths in West Africa. Recently E. ocellatus underwent taxonomic revision and was split into two species, E. ocellatus sensu stricto and E. romani, leading to questions regarding differences in venom bioactivities and the efficacy of antivenoms indicated for treatment of 'E. ocellatus' envenoming against the two redefined species. Using a range of in vitro assays we compared the toxin activities of the two species and the venom-neutralising efficacy of three antivenoms (EchiTAbG, SAIMR Echis and Echiven) raised against 'E. ocellatus'. We then used murine preclinical assays to compare the in vivo efficacy of these antivenoms against E. romani a"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Preclinical evaluation of the neutralising efficacy of three antivenoms against the venoms of the recently taxonomically partitioned E. ocellatus and E. romani."],"pmcid":["PMC12321083"],"funding_grant_id":["NC/X001172/1","221712/Z/20/Z"],"pubmed_authors":["Xie T","Casewell NR","Menzies SK","Crittenden EP","Edge RJ","Marriott AE","Dawson CA","Keen M","Wilkinson MC","Wuster W","Ainsworth S"],"additional_accession":[]},"is_claimable":false,"name":"Preclinical evaluation of the neutralising efficacy of three antivenoms against the venoms of the recently taxonomically partitioned E. ocellatus and E. romani.","description":"Snakebite is a significant public health concern in Africa, with the viperid species Echis ocellatus being responsible for the majority of snakebite deaths in West Africa. Recently E. ocellatus underwent taxonomic revision and was split into two species, E. ocellatus sensu stricto and E. romani, leading to questions regarding differences in venom bioactivities and the efficacy of antivenoms indicated for treatment of 'E. ocellatus' envenoming against the two redefined species. Using a range of in vitro assays we compared the toxin activities of the two species and the venom-neutralising efficacy of three antivenoms (EchiTAbG, SAIMR Echis and Echiven) raised against 'E. ocellatus'. We then used murine preclinical assays to compare the in vivo efficacy of these antivenoms against E. romani a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-31T11:47:13.012Z","creation":"2025-09-01T03:06:02.688Z"},"accession":"S-EPMC12321083","cross_references":{"pubmed":["40758764"],"doi":["10.1371/journal.pntd.0013371"]}}