biostudies-literatureGottschalk SEuropean Union’s Horizon 2020 research and innovation programme683-690https://www.ebi.ac.uk/biostudies/studies/S-EPMC12322465biostudies-literatureUnknown17(7)<h4>Background</h4>Recent studies, including the TENSION trial, support the use of endovascular thrombectomy (EVT) in acute ischemic stroke with large infarct (Alberta Stroke Program Early Computed Tomography Score (ASPECTS) 3-5).<h4>Objective</h4>To evaluate the cost-effectiveness of EVT compared with best medical care (BMC) alone in this population from a German healthcare payer perspective.<h4>Methods</h4>A short-term decision tree and a long-term Markov model (lifetime horizon) were used to compare healthcare costs and quality-adjusted life years (QALYs) between EVT and BMC. The effectiveness of EVT was reflected by the 90-day modified Rankin Scale (mRS) outcome from the TENSION trial. QALYs were based on published mRS-specific health utilities (EQ-5D-3L indices). Long-term healthcare Journal of neurointerventional surgeryCost-effectiveness of endovascular thrombectomy for acute ischemic stroke with established large infarct in Germany: a decision tree and Markov model.PMC12322465754640Bendszus MBonekamp SThomalla GZelenak KKrajina ASimonsen CZHill MDGottschalk SAamodt AHKonig HHFuentes BGizewski ERSubtil FPierot LDenis ADams JfalseCost-effectiveness of endovascular thrombectomy for acute ischemic stroke with established large infarct in Germany: a decision tree and Markov model.<h4>Background</h4>Recent studies, including the TENSION trial, support the use of endovascular thrombectomy (EVT) in acute ischemic stroke with large infarct (Alberta Stroke Program Early Computed Tomography Score (ASPECTS) 3-5).<h4>Objective</h4>To evaluate the cost-effectiveness of EVT compared with best medical care (BMC) alone in this population from a German healthcare payer perspective.<h4>Methods</h4>A short-term decision tree and a long-term Markov model (lifetime horizon) were used to compare healthcare costs and quality-adjusted life years (QALYs) between EVT and BMC. The effectiveness of EVT was reflected by the 90-day modified Rankin Scale (mRS) outcome from the TENSION trial. QALYs were based on published mRS-specific health utilities (EQ-5D-3L indices). Long-term healthcare 2025-01-01T00:00:00Z2025 Jun2026-07-15T12:51:11.335Z2025-09-01T03:05:56.518ZS-EPMC123224653890668810.1136/jnis-2024-021837